Al-Braik Fatima A, Rutter Paul M, Hasan Mohamed Y, Brown David T
Drug Registration and Control Department, Ministry of Health, PO Box 31854, Abu Dhabi, United Arab Emirates.
Saudi Med J. 2011 Feb;32(2):171-6.
To provide data on herbal medicine (HM) use and safety in patients attending a nephrology clinic at Sheikh Khalifa Medical City (SKMC), Abu Dhabi, United Arab Emirates (UAE).
A prospective, 3-month study between June and September 2007, investigated all patients presenting to the Nephrology Clinic of the Sheikh Khalifa Medical center (SKMC) in Abu Dhabi, UAE. A structured questionnaire determined previous and current HM use, and descriptions of associated adverse reactions. Corroborating evidence was sought from the patient's medical records. Causality was assessed by consensus from an expert panel using the Naranjo algorithm.
The HM use was widespread (468 of 688; 68%). Over two-thirds (69%) reported currently taking 3 or more herbal preparations. Patients reported using over 100 different HMs, many of them compounded mixtures; 35% could not identify a single ingredient of these mixtures, and 70% had not informed the clinic doctors that they were taking HMs. Just 2 patients had HM use recorded in their medical record. Twenty-eight HM-related adverse reactions were identified in 26 (5.6%) patients; 12 probably and 16 possibly related to HMs. Seven involved HMs alone and 21, a HM/prescription medication (PM) interaction.
The use of HMs in patients with underlying kidney problems was extensive and contributed additional pathology to the underlying renal disease, either alone or in combination with PMs. The reluctance of patients to inform their healthcare providers of concurrent use highlights a need to take a thorough drug history on clinic registration.
提供关于阿拉伯联合酋长国阿布扎比谢赫哈利法医疗城（SKMC）肾病门诊患者使用草药及其安全性的数据。
2007年6月至9月进行了一项为期3个月的前瞻性研究，调查了阿联酋阿布扎比谢赫哈利法医疗中心（SKMC）肾病门诊的所有患者。通过结构化问卷确定既往和当前的草药使用情况以及相关不良反应的描述。从患者的病历中寻找佐证证据。使用纳朗霍算法由专家小组通过共识评估因果关系。
草药使用很普遍（688例中的468例；68%）。超过三分之二（69%）的患者报告目前正在服用3种或更多种草药制剂。患者报告使用了100多种不同的草药，其中许多是复方混合物；35%的患者无法识别这些混合物中的单一成分，70%的患者未告知门诊医生他们正在服用草药。只有2例患者的病历中有使用草药的记录。在26例（5.6%）患者中发现了28例与草药相关的不良反应；12例可能与草药有关，16例可能有关。7例仅涉及草药，21例涉及草药/处方药（PM）相互作用。
患有潜在肾脏问题的患者广泛使用草药，这单独或与处方药联合为潜在的肾脏疾病增添了额外的病理情况。患者不愿告知医护人员同时使用草药的情况，这突出表明在门诊登记时需要全面了解用药史。
