基质金属蛋白酶 7 与 HIV 感染中的脑萎缩有显著关系。
Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection.
机构信息
Department of Radiology, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL 60611-2927, USA.
出版信息
J Neurovirol. 2011 Apr;17(2):153-8. doi: 10.1007/s13365-011-0018-5. Epub 2011 Feb 8.
Abstract
Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.
摘要
研究发现，循环基质金属蛋白酶（MMP-1 和 MMP-7）水平与感染 HIV 的患者的脑损伤严重程度相关。本研究使用高分辨率神经解剖成像和自动分割算法来阐明这种关系。两种金属蛋白酶均与脑脊液体积分数增加显著相关。全面的脑容量分析显示，MMP-7 与萎缩的关系更为显著，它与多个脑区的神经损伤以及几乎所有脑室测量值均显著相关。MMP-7 还与病毒学和认知状态的测量值相关。
相似文献
1
Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection.
J Neurovirol. 2011 Apr;17(2):153-8. doi: 10.1007/s13365-011-0018-5. Epub 2011 Feb 8.
2
Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection.
J Neurovirol. 2009 May;15(3):275-81. doi: 10.1080/13550280902913271.
3
Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status.
J Neurovirol. 2013 Oct;19(5):452-60. doi: 10.1007/s13365-013-0197-3. Epub 2013 Aug 27.
4
Increased activity of matrix metalloproteinases in the cerebrospinal fluid of patients with HIV-associated neurological diseases.
J Neurovirol. 2000 Apr;6(2):156-63. doi: 10.3109/13550280009013159.
5
Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies.
J Neurovirol. 2011 Aug;17(4):368-79. doi: 10.1007/s13365-011-0033-6. Epub 2011 May 10.
6
Clinical factors related to brain structure in HIV: the CHARTER study.
J Neurovirol. 2011 Jun;17(3):248-57. doi: 10.1007/s13365-011-0032-7. Epub 2011 May 5.
7
Dynamics of peripheral T cell exhaustion and monocyte subpopulations in neurocognitive impairment and brain atrophy in chronic HIV infection.
J Neurovirol. 2024 Dec;30(5-6):489-499. doi: 10.1007/s13365-024-01223-w. Epub 2024 Jun 29.
8
Low blood CD8+ T-lymphocytes and high circulating monocytes are predictors of HIV-1-associated progressive encephalopathy in children.
Pediatrics. 2003 Feb;111(2):E168-75. doi: 10.1542/peds.111.2.e168.
9
Mild brain atrophy in early HIV infection: the lack of association with cognitive deficits and HIV-specific intrathecal immune response.
J Neurol Sci. 1990 Nov;99(2-3):121-36. doi: 10.1016/0022-510x(90)90149-h.
10
Cognitive disorders in HIV-infected patients: are they HIV-related?
AIDS. 2013 Jan 28;27(3):391-400. doi: 10.1097/QAD.0b013e32835b1019.
引用本文的文献
1
Relationship between Cerebrospinal Fluid Matrix Metalloproteinases Levels and Brain Amyloid Deposition in Mild Cognitive Impairment.
Biomolecules. 2021 Oct 11;11(10):1496. doi: 10.3390/biom11101496.
2
Noncontiguous Protein Interaction Domains in Osteopontin Contribute to Enhance HIV-1 Replication.
J Hum Virol Retrovirol. 2014;1(1):7-14. doi: 10.15406/jhvrv.2014.01.00003. Epub 2014 May 23.
3
Increased matrix metalloproteinase levels and perineuronal net proteolysis in the HIV-infected brain; relevance to altered neuronal population dynamics.
Exp Neurol. 2020 Jan;323:113077. doi: 10.1016/j.expneurol.2019.113077. Epub 2019 Oct 31.
4
HIV-1 Tat promotes astrocytic release of CCL2 through MMP/PAR-1 signaling.
Glia. 2019 Sep;67(9):1719-1729. doi: 10.1002/glia.23642. Epub 2019 May 23.
5
Determinants of HIV-induced brain changes in three different periods of the early clinical course: A data mining analysis.
Neuroimage Clin. 2015 Aug 1;9:75-82. doi: 10.1016/j.nicl.2015.07.012. eCollection 2015.
6
Dynamic nature of the p75 neurotrophin receptor in response to injury and disease.
J Neuroimmune Pharmacol. 2014 Dec;9(5):615-28. doi: 10.1007/s11481-014-9566-9. Epub 2014 Sep 20.
7
Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status.
J Neurovirol. 2013 Oct;19(5):452-60. doi: 10.1007/s13365-013-0197-3. Epub 2013 Aug 27.
8
Expression of substance P, neurokinin-1 receptor and immune markers in the brains of individuals with HIV-associated neuropathology.
J Neurol Sci. 2013 Nov 15;334(1-2):18-23. doi: 10.1016/j.jns.2013.07.008. Epub 2013 Aug 2.
9
Platelet decline as a predictor of brain injury in HIV infection.
J Neurovirol. 2011 Oct;17(5):487-95. doi: 10.1007/s13365-011-0053-2. Epub 2011 Sep 29.
本文引用的文献
1
Interaction of HIV Tat and matrix metalloproteinase in HIV neuropathogenesis: a new host defense mechanism.
FASEB J. 2006 Aug;20(10):1736-8. doi: 10.1096/fj.05-5619fje. Epub 2006 Jun 28.
2
Diffusion alterations in corpus callosum of patients with HIV.
AJNR Am J Neuroradiol. 2006 Mar;27(3):656-60.
3
Matrix metalloproteinase-7 disrupts dendritic spines in hippocampal neurons through NMDA receptor activation.
J Neurochem. 2006 Apr;97(1):44-56. doi: 10.1111/j.1471-4159.2006.03701.x. Epub 2006 Mar 3.
4
Novel role of TGF-beta in differential astrocyte-TIMP-1 regulation: implications for HIV-1-dementia and neuroinflammation.
J Neurosci Res. 2006 May 15;83(7):1271-80. doi: 10.1002/jnr.20787.
5
Diffusion-tensor MR imaging of the brain in human immunodeficiency virus-positive patients.
AJNR Am J Neuroradiol. 2005 Oct;26(9):2275-81.
6
MMP-7 promoter polymorphisms do not influence CD4+ recovery and changes in plasma viral load during antiretroviral therapy for HIV-1 infection.
Int J Immunogenet. 2005 Oct;32(5):269-71. doi: 10.1111/j.1744-313X.2005.00523.x.
7
Diffusion tensor imaging of subcortical brain injury in patients infected with human immunodeficiency virus.
J Neurovirol. 2005 Jul;11(3):292-8. doi: 10.1080/13550280590953799.
8
Disease burden in HIV-associated cognitive impairment: a study of whole-brain imaging measures.
Neurology. 2004 Dec 28;63(12):2293-7. doi: 10.1212/01.wnl.0000147477.44791.bd.
9
Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia.
Neurology. 2004 Dec 14;63(11):2084-90. doi: 10.1212/01.wnl.0000145763.68284.15.
10
Matrix metalloproteinases as modulators of inflammation and innate immunity.
Nat Rev Immunol. 2004 Aug;4(8):617-29. doi: 10.1038/nri1418.
Zotero 插件