[肿瘤标志物在胸腔积液中的诊断价值]
[Diagnostic value of tumor markers in pleural effusions].
作者信息
Botte G, Laferrere L, Etchepare S, Dalurzo D, Duhart J E, Adaro F V
机构信息
Servicio de Clínica Médica I, Complejo Médico-Policial Churruca-Visca, Buenos Aires, Argentina.
出版信息
Medicina (B Aires). 1990;50(3):213-6.
In order to discriminate between benign and malignant effusions, the value of alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and beta subunit of human chorionic gonadotropin (GNCH Sub-beta) has been estimated in pleural exudates. A sample of 65 patients, 33 with a malignant (histologically and/or cytologically established) and 32 with a benign effusion was analysed. Only mean CEA in malignant effusions was significantly higher than in benign effusions (p less than 0.01). In the detection of malignant effusion CEA showed a sensitivity of 57% and a specificity of 97%; AFP a sensitivity of 9% and a specificity of 97% and GNCH Sub beta a sensitivity of 9% and a specificity of 90%.
为了鉴别良性和恶性胸腔积液，对胸膜渗出液中的甲胎蛋白（AFP）、癌胚抗原（CEA）及人绒毛膜促性腺激素β亚基（GNCH Sub-beta）的价值进行了评估。分析了65例患者的样本，其中33例为恶性胸腔积液（经组织学和/或细胞学确诊），32例为良性胸腔积液。只有恶性胸腔积液中的CEA均值显著高于良性胸腔积液（p<0.01）。在检测恶性胸腔积液时，CEA的敏感性为57%，特异性为97%；AFP的敏感性为9%，特异性为97%；GNCH Sub-beta的敏感性为9%，特异性为90%。
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