大鼠主要组织相容性复合体 RT-1：Ⅱ. 复杂遗传组织的生化证据。
The major histocompatibility complex of the rat,RT 1 : II. biochemical evidence for a complex genetic organization.
机构信息
The Wistar Institute for Anatomy and Biology, Philadelphia, Pennsylvania.
出版信息
Immunogenetics. 1978 Dec;7(1):507-14. doi: 10.1007/BF01844040.
Recombinational analysis has shown that the rat MHC,RT1 is divided into two regions:RT1.A, which codes for class I (transplantation) antigens, andRT1.B, which controls the humoral immune response and proliferative response to allogeneic cells as well as the expression of class II (Ia) antigens. Serological and sequence studies suggest that there might be more than one antigen-coding locus within theRT1.A region. Results obtained by sequential immunoprecipitation reveal that both regions code for at least two gene products. By implication, theRT1 complex must therefore harbor at least four loci;RT1.A andD coding for class I glycoproteins (45,000 daltons); andRT1.B andE coding for class II (Ia) glycoproteins (35,000 and 28,000 daltons).
重组分析表明，大鼠 MHC，RT1 分为两个区域：RT1.A，编码 I 类（移植）抗原，以及 RT1.B，控制体液免疫反应和对同种异体细胞的增殖反应以及 II 类（Ia）抗原的表达。血清学和序列研究表明，RT1.A 区域内可能存在不止一个抗原编码基因座。通过连续免疫沉淀获得的结果表明，这两个区域至少编码两个基因产物。因此，可以推断 RT1 复合物必须至少含有四个基因座；RT1.A 和 D 编码 I 类糖蛋白（45000 道尔顿）；以及 RT1.B 和 E 编码 II 类（Ia）糖蛋白（35000 和 28000 道尔顿）。
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