Haustein D, Stock W, Günther E
Immunogenetics. 1982 Mar;15(3):271-7. doi: 10.1007/BF00364335.
The RT1.C region has recently been defined genetically as a third region of the rat major histocompatibility system, RT1, and has been shown to code for cell-surface antigens with restricted tissue distribution (present on lymphocytes and absent from red blood cells and liver) and for target antigens of unrestricted cytotoxic T lymphocytes. Immunoprecipitation with C-antigen-specific alloantisera and SDS-PAGE analysis, reveal that C-region products are glycoproteins composed of molecules of 40 500-43 000 and 12 500 molecular weight, respectively. Thus, the RT1.B region, which codes for class II molecules, is flanked by RT1 regions which determine class I molecules (as defined biochemically), which are either expressed ubiquitously (RT1.A antigens) or in a restricted manner (RT1.C products). The homology to H-2Qa antigens is discussed.
RT1.C区域最近在遗传学上被定义为大鼠主要组织相容性系统RT1的第三个区域，并且已证明它编码具有受限组织分布的细胞表面抗原（存在于淋巴细胞上，不存在于红细胞和肝脏中）以及不受限细胞毒性T淋巴细胞的靶抗原。用C抗原特异性同种抗血清进行免疫沉淀和SDS-PAGE分析表明，C区域产物是糖蛋白，分别由分子量为40500 - 43000和12500的分子组成。因此，编码II类分子的RT1.B区域两侧是决定I类分子的RT1区域（如生化定义），这些I类分子要么普遍表达（RT1.A抗原），要么以受限方式表达（RT1.C产物）。文中还讨论了与H-2Qa抗原的同源性。
