Burghaus L, Fink G R, Erdmann E, Müller-Ehmsen J
Klinik und Poliklinik für Neurologie, Uniklinik Köln, Köln.
Dtsch Med Wochenschr. 2011 Feb;136(7):315-9. doi: 10.1055/s-0031-1272530. Epub 2011 Feb 7.
Sudden loss of consciousness can be caused by syncope or epileptic seizure, which therefore requires a diagnostic work-up including cardiological and neurological examinations. Thus, in clinical practice cooperation of these two medical specialties is common and of high relevance. Seizures may lead to cardiac arrhythmia or ictal asystole, and "sudden unexpected death in epilepsy" (SUDEP) is an important field of epilepsy research. Cardiac channelopathies such as long QT syndrome may be associated with seizures, suggesting a possible link between cardiac and cerebral channelopathy. We here review in detail cardiac effects due to epileptic seizures as well as possible pathogenetic correlations between cardiac and epileptic diseases.
意识突然丧失可能由晕厥或癫痫发作引起,因此需要进行包括心脏和神经学检查在内的诊断性检查。因此,在临床实践中,这两个医学专科的合作很常见且具有高度相关性。癫痫发作可能导致心律失常或发作性心搏停止,“癫痫猝死”(SUDEP)是癫痫研究的一个重要领域。诸如长QT综合征等心脏离子通道病可能与癫痫发作有关,提示心脏和脑部离子通道病之间可能存在联系。我们在此详细综述癫痫发作对心脏的影响以及心脏和癫痫疾病之间可能的发病机制关联。