Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
Demography. 2010;47 Suppl(Suppl 1):S41-64. doi: 10.1353/dem.2010.0005.
The incorporation of biological information in large population surveys has expanded demographic analysis to clarify the meaning of observed trends and differences in population health and mortality. Levels of measured biological risk in the population were reduced in recent years largely because of the expanded use of prescription drugs. The increased use of antihypertensives and, to a lesser extent, lipid-lowering drugs was a likely cause of significant mortality reduction. Blacks and persons with lower educational attainment experience higher levels of biological risk factors, more diseases, and more frailty; these differences are the sources of higher mortality for these groups. Hispanics are less likely to have a higher prevalence of risk factors and diseases than the non-Hispanic population, providing further understanding of the "Hispanic paradox." Almost every examined indicator of biological risk, disease, and frailty is related to higher mortality, indicating how incorporation of this information provides a fuller understanding of the morbidity process.
将生物学信息纳入大型人群调查中,扩展了人口统计学分析,以阐明人群健康和死亡率中观察到的趋势和差异的意义。近年来,由于处方药物的广泛使用,人群中测量的生物风险水平有所降低。抗高血压药物的使用增加,在较小程度上,降脂药物的使用增加,可能是导致死亡率显著降低的原因。黑人以及受教育程度较低的人群,其生物风险因素、疾病和虚弱程度更高;这些差异是这些人群死亡率较高的原因。与非西班牙裔人群相比,西班牙裔人群的风险因素和疾病患病率较低,这进一步说明了“西班牙裔悖论”的原因。几乎每一个被检查的生物风险、疾病和虚弱的指标都与更高的死亡率有关,这表明纳入这些信息如何提供对发病过程的更全面理解。