HCC Translational Research Laboratory, Barcelona-Clinic Liver Cancer Group, Institut d'Investigacions Biomèdiques Agust Pi i Sunyer, Liver Unit, CIBERehd. Hospital Clinic, Catalonia, Spain.
Alcohol Clin Exp Res. 2011 May;35(5):821-5. doi: 10.1111/j.1530-0277.2010.01406.x. Epub 2011 Feb 8.
Hepatocellular carcinoma (HCC) is one of the major causes of death among cirrhotic patients, being viral hepatitis and alcohol abuse, the main risk factors for its development. The introduction of highly sophisticated genomic technologies has spurred extensive research on the molecular pathogenesis of this devastating disease. Several signaling cascades have been consistently found dysregulated in HCC (e.g., WNT-β-catenin, PI3K/AKT/MTOR, RAS/MAPK, IGF, HGF/MET, VEGF, EGFR, and PDGF). In addition, there have been numerous molecular classifications proposed for this disease, what provides an additional hint about its genomic complexity. The importance of knowing the molecular drivers of HCC is underscored by the positive results of a molecular targeted agent, sorafenib, able to improve survival in patients with advanced disease. This review will briefly outline key concepts in alcohol-related hepatocarcinogenesis, and provide some insight regarding current trends in translating HCC genomics into clinical management of the disease.
肝细胞癌 (HCC) 是肝硬化患者死亡的主要原因之一，病毒肝炎和酗酒是其发展的主要危险因素。高度复杂的基因组技术的出现推动了对这种毁灭性疾病的分子发病机制的广泛研究。已经发现几种信号级联在 HCC 中失调（例如，WNT-β-catenin、PI3K/AKT/MTOR、RAS/MAPK、IGF、HGF/MET、VEGF、EGFR 和 PDGF）。此外，已经提出了许多用于这种疾病的分子分类，这为其基因组复杂性提供了额外的提示。了解 HCC 分子驱动因素的重要性得到了分子靶向药物索拉非尼的积极结果的强调，该药物能够改善晚期疾病患者的生存。这篇综述将简要概述与酒精相关的肝癌发生的关键概念，并就将 HCC 基因组学转化为疾病的临床管理方面的当前趋势提供一些见解。
