Department of Small Animal Clinical Sciences, The Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark.
Vet Comp Oncol. 2011 Mar;9(1):16-37. doi: 10.1111/j.1476-5829.2010.00233.x. Epub 2010 Aug 16.
Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.
缺氧诱导因子 (HIFs) 在肿瘤缺氧时的细胞反应中起着关键作用，介导适应性反应，使缺氧细胞能够在恶劣的环境中存活。鉴定和理解肿瘤缺氧及其对细胞过程的影响具有重要的预后信息，并可能有助于确定潜在的缺氧规避和靶向策略。本文综述了目前关于肿瘤细胞中 HIF 调节和功能的知识，并讨论了将伴侣动物作为比较自发性癌症模型的应用。伴侣动物的自发性肿瘤具有巨大的研究潜力，可用于评估和理解肿瘤缺氧，并开发针对缺氧的治疗方法。
