癫痫发生的神经影像学生物标志物。
Neuroimaging biomarkers of epileptogenesis.
机构信息
Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
出版信息
Neurosci Lett. 2011 Jun 27;497(3):194-204. doi: 10.1016/j.neulet.2011.01.076. Epub 2011 Feb 16.
Abstract
Much progress has been made in the field studying the process of epileptogenesis via neuroimaging techniques. Conventional imaging methods include magnetic resonance imaging with morphometric analysis, magnetic resonance spectroscopy and positron emission tomography. Newer network-based methods such as diffusion tensor imaging and functional magnetic resonance imaging with resting functional connectivity are being developed and applied to clinical use. This review provides a brief summary of the major human and animal studies in both partial and generalized epilepsies that demonstrate the potential of these imaging modalities to serve as biomarkers of epileptogenesis.
摘要
在使用神经影像学技术研究癫痫发生过程的领域取得了很大进展。传统的成像方法包括形态计量学磁共振成像、磁共振波谱和正电子发射断层扫描。较新的基于网络的方法，如弥散张量成像和静息功能磁共振成像连接，正在被开发并应用于临床。这篇综述简要总结了部分和全面性癫痫的主要人体和动物研究，这些研究表明这些成像方式有潜力作为癫痫发生的生物标志物。
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本文引用的文献
1
Resting functional connectivity between the hemispheres in childhood absence epilepsy.儿童失神癫痫半球间静息功能连接。
Neurology. 2011 Jun 7;76(23):1960-7. doi: 10.1212/WNL.0b013e31821e54de.
2
Effects of childhood absence epilepsy on associations between regional cortical morphometry and aging and cognitive abilities.儿童失神癫痫对皮质形态计量学与年龄和认知能力之间相关性的影响。
Hum Brain Mapp. 2011 Apr;32(4):580-91. doi: 10.1002/hbm.21045.
3
Cerebellum abnormalities in idiopathic generalized epilepsy with generalized tonic-clonic seizures revealed by diffusion tensor imaging.弥散张量成像显示特发性全面性癫痫伴全面性强直-阵挛发作的小脑异常。
PLoS One. 2010 Dec 21;5(12):e15219. doi: 10.1371/journal.pone.0015219.
4
Connectivity of the supplementary motor area in juvenile myoclonic epilepsy and frontal lobe epilepsy.青少年肌阵挛癫痫和额叶癫痫的辅助运动区连通性。
Epilepsia. 2011 Mar;52(3):507-14. doi: 10.1111/j.1528-1167.2010.02770.x. Epub 2010 Nov 3.
5
Simultaneous EEG, fMRI, and behavior in typical childhood absence seizures.典型儿童失神发作时的 EEG、fMRI 和行为同步研究。
Epilepsia. 2010 Oct;51(10):2011-22. doi: 10.1111/j.1528-1167.2010.02652.x.
6
BOLD signal changes preceding negative responses in EEG-fMRI in patients with focal epilepsy.在局灶性癫痫患者的 EEG-fMRI 中，负反应前的 BOLD 信号变化。
Epilepsia. 2010 Sep;51(9):1837-45. doi: 10.1111/j.1528-1167.2010.02643.x. Epub 2010 Jun 7.
7
Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRI.内侧颞叶癫痫的不对称海马连接：静息态 fMRI 的证据。
BMC Neurosci. 2010 Jun 2;11:66. doi: 10.1186/1471-2202-11-66.
8
Voxel-based morphometry and epilepsy.基于体素的形态计量学与癫痫
Expert Rev Neurother. 2010 Jun;10(6):975-84. doi: 10.1586/ern.10.63.
9
Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging.典型儿童失神发作的动态时间过程：脑电图、行为和功能磁共振成像。
J Neurosci. 2010 Apr 28;30(17):5884-93. doi: 10.1523/JNEUROSCI.5101-09.2010.
10
Thalamic changes in temporal lobe epilepsy with and without hippocampal sclerosis: a diffusion tensor imaging study.伴有和不伴有海马硬化的颞叶癫痫的丘脑变化：一项弥散张量成像研究。
Epilepsy Res. 2010 Jun;90(1-2):21-7. doi: 10.1016/j.eplepsyres.2010.03.002. Epub 2010 Mar 21.
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