Szabo C Akos, Salinas Felipe S
Department of Neurology, University of Texas Health San Antonio, San Antonio, TX, United States.
Research Imaging Institute, University of Texas Health San Antonio, San Antonio, TX, United States.
Front Vet Sci. 2022 Jul 14;9:908801. doi: 10.3389/fvets.2022.908801. eCollection 2022.
Characterization of baboon model of genetic generalized epilepsy (GGE) is driven both electroclinically and by successful adoption of neuroimaging platforms, such as magnetic resonance imaging (MRI) and positron emission tomography (PET). Based upon its phylogenetic proximity and similar brain anatomy to humans, the epileptic baboon provides an excellent translational model. Its relatively large brain size compared to smaller nonhuman primates or rodents, a gyrencephalic structure compared to lissencephalic organization of rodent brains, and the availability of a large pedigreed colony allows exploration of neuroimaging markers of diseases. Similar to human idiopathic generalized epilepsy (IGE), structural imaging in the baboon is usually normal in individual subjects, but gray matter volume/concentration (GMV/GMC) changes are reported by statistical parametric mapping (SPM) analyses. Functional neuroimaging has been effective for mapping the photoepileptic responses, the epileptic network, altered functional connectivity of physiological networks, and the effects of anti-seizure therapies. This review will provide insights into our current understanding the baboon model of GGE through functional and structural imaging.
遗传性全身性癫痫（GGE）狒狒模型的特征描述是通过临床电生理以及成功采用神经影像学平台（如磁共振成像（MRI）和正电子发射断层扫描（PET））来实现的。基于其与人类在系统发育上的接近性以及相似的脑解剖结构，癫痫狒狒提供了一个出色的转化模型。与较小的非人灵长类动物或啮齿动物相比，其脑容量相对较大；与啮齿动物大脑的无脑回结构相比，具有脑回结构；并且有大量纯种群体，这使得对疾病的神经影像学标志物进行探索成为可能。与人类特发性全身性癫痫（IGE）相似，狒狒个体的结构成像通常正常，但统计参数映射（SPM）分析报告了灰质体积/浓度（GMV/GMC）的变化。功能神经影像学在绘制光癫痫反应、癫痫网络、生理网络功能连接改变以及抗癫痫治疗效果方面一直很有效。本综述将通过功能和结构成像，深入探讨我们目前对GGE狒狒模型的理解。
