Storstein Anette, Helseth Eirik, Johannesen Tom Børge, Schellhorn Till, Mørk Sverre, van Helvoirt René
Nevrologisk avdeling, Haukeland universitetssykehus, Seksjon for nevrologiInstitutt for klinisk medisin, Universitetet i Bergen, Bergen.
Tidsskr Nor Laegeforen. 2011 Feb 4;131(3):238-41. doi: 10.4045/tidsskr.09.1362.
High-grade glioma is a primary malignant brain tumour which affects about 200 Norwegian patients each year. Diagnosis and treatment of high-grade gliomas in adults has been reviewed.
The article is based on recent literature retrieved through a non-systematic search in PubMed and the authors' experience with the patient group.
The most common symptoms are focal neurological deficits, epileptic seizures and pressure symptoms. The patients should be examined by magnetic resonance (MR) imaging and the diagnosis confirmed with biopsy. No curative treatment is currently available for high-grade gliomas. The standard treatment is surgical resection followed by radiation therapy alone or in combination with chemotherapy (temozolomid). Five-year survival is only 6.1 %.
The diagnosis is composite with both neurological symptoms and cognitive problems. This requires good communication with the patient and close cooperation between various departments and the primary health services. Symptomatic treatment and multidisciplinary follow-up is necessary.
高级别胶质瘤是一种原发性恶性脑肿瘤，每年约影响200名挪威患者。本文对成人高级别胶质瘤的诊断和治疗进行了综述。
本文基于通过在PubMed上非系统检索获取的近期文献以及作者对该患者群体的经验。
最常见的症状是局灶性神经功能缺损、癫痫发作和压迫症状。患者应接受磁共振（MR）成像检查，并通过活检确诊。目前高级别胶质瘤尚无治愈性治疗方法。标准治疗是手术切除，随后单独进行放射治疗或联合化疗（替莫唑胺）。五年生存率仅为6.1%。
该诊断兼具神经症状和认知问题。这需要与患者进行良好沟通，以及各科室与基层医疗服务之间的密切合作。对症治疗和多学科随访是必要的。
