腹侧被盖区神经元群体对运动信号的联合处理。
Conjunctive processing of locomotor signals by the ventral tegmental area neuronal population.
机构信息
Key Laboratory of MOE and STCSM, Shanghai Institute of Brain Functional Genomics, East China Normal University, Shanghai, China.
出版信息
PLoS One. 2011 Jan 27;6(1):e16528. doi: 10.1371/journal.pone.0016528.
The ventral tegmental area (VTA) plays an essential role in reward and motivation. How the dopamine (DA) and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-DA neurons simultaneously in the VTA of awake mice engaged in motivated voluntary movements such as wheel running. Our results revealed that VTA non-DA neurons exhibited significant rhythmic activity that was correlated with the animal's running rhythms. Activity of putative DA neurons also correlated with the movement behavior, but to a lesser degree. More importantly, putative DA neurons exhibited significant burst activation at both onset and offset of voluntary movements. These findings suggest that VTA DA and non-DA neurons conjunctively process locomotor-related motivational signals that are associated with movement initiation, maintenance and termination.
腹侧被盖区（VTA）在奖励和动机中起着至关重要的作用。VTA 中的多巴胺（DA）和非 DA 神经元如何参与基于动机的运动行为尚不清楚。我们在清醒小鼠的 VTA 中同时记录了推定的 DA 和非 DA 神经元的活动，这些小鼠参与了自愿运动，例如跑步。我们的结果表明，VTA 中的非 DA 神经元表现出与动物跑步节奏相关的显著节律性活动。假定的 DA 神经元的活动也与运动行为相关，但程度较小。更重要的是，假定的 DA 神经元在自愿运动的开始和结束时都表现出显著的爆发激活。这些发现表明，VTA 的 DA 和非 DA 神经元共同处理与运动起始、维持和终止相关的与运动相关的动机信号。
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