Mendelson N H
Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721.
Sci Prog. 1990;74(296 Pt 4):425-41.
Bacterial macrofibres are highly ordered multicellular, helically twisted structures that provide a unique opportunity for studying fundamental growth processes and morphogenesis in a procaryotic model. The complex fibres arise, starting either from a single spore or a vegetative cell by the deformation of individual cell shape from cylindrical to helical and the folding and plying of chains of cells into multicellular twisted structures. The dynamics of fibre morphogenesis can be traced to hierarchical interactions beginning with the assembly of cell-wall polymers. Both genetic and biomechanical factors govern the formation and heritability of macrofibre twist states, which can range over the entire spectrum from maximum left- to maximum right-handedness. Forces that arise during growth influence individual cells and their interactions with other cells. Morphogenesis results from the manner in which the cell-wall materials respond to these and other forces. Significant parameters governing response to force are cell wall geometry, visco-elasticity and anisotrophy.
细菌大纤维是高度有序的多细胞螺旋扭曲结构，为研究原核模型中的基本生长过程和形态发生提供了独特的机会。复杂的纤维要么从单个孢子开始形成，要么从营养细胞开始形成，通过单个细胞形状从圆柱形变为螺旋形，以及细胞链折叠和缠绕形成多细胞扭曲结构。纤维形态发生的动力学可以追溯到从细胞壁聚合物组装开始的分级相互作用。遗传和生物力学因素都控制着大纤维扭曲状态的形成和遗传性，其范围可以从最大左旋到最大右旋的整个光谱。生长过程中产生的力影响单个细胞及其与其他细胞的相互作用。形态发生源于细胞壁材料对这些力和其他力的响应方式。控制对力响应的重要参数是细胞壁几何形状、粘弹性和各向异性。
