Department of Food Science and Nutrition, Laval University, Quebec City, Canada.
Acta Obstet Gynecol Scand. 2011 May;90(5):524-30. doi: 10.1111/j.1600-0412.2011.01094.x. Epub 2011 Mar 16.
Recent studies have shown that high interleukin-6 (IL-6) secretion may aggravate insulin resistance in pregnancy and participate in the pathogenesis of gestational diabetes mellitus (GDM). The aim of this study was to determine whether the presence of GDM is associated with elevated IL-6 concentrations and whether this association remains after delivery, independent of body mass index.
Longitudinal study.
Hospital-based.
Forty-seven women were screened for GDM with a 75g oral glucose tolerance test at 26.1±3.7 weeks of pregnancy following the Canadian Diabetes Association guidelines (20 GDM, 27 control subjects).
Interleukin-6 levels were measured by ELISA at the time of GDM screening and two months post-partum.
Interleukin-6 concentrations were significantly higher in women with GDM compared with control women at the time of GDM screening (1.47±0.72 vs. 0.90±0.32pg/mL, p≤0.01). Similar results were obtained two months post-partum, where IL-6 levels remained significantly higher in women with GDM compared with control women (1.88±0.85 vs. 1.41±0.87pg/mL, p≤0.05). Interleukin-6 concentrations were significantly correlated with the Matsuda insulin sensitivity index, measured at the two time points (r=-0.60, p≤0.01 and r=-0.34, p≤0.05). The Matsuda insulin sensitivity index was an independent and significant predictor of IL-6 concentrations at the time of GDM screening, explaining 35.6% of the variance (p≤0.0001) in this variable. IL-6 concentration measured at GDM screening was identified as an independent and significant predictor of post-partum IL-6 concentrations, explaining 28.6% of the variance (p≤0.001).
These results show that GDM is associated with elevated IL-6 levels independent of obesity levels, both during pregnancy and after delivery.
最近的研究表明，高白细胞介素-6（IL-6）分泌可能加重妊娠期间的胰岛素抵抗，并参与妊娠糖尿病（GDM）的发病机制。本研究旨在确定 GDM 是否与升高的 IL-6 浓度有关，以及这种关联是否在分娩后独立于体重指数存在。
纵向研究。
医院。
根据加拿大糖尿病协会指南（26.1±3.7 周妊娠时的 75g 口服葡萄糖耐量试验），47 名妇女被筛查 GDM（20 名 GDM，27 名对照）。
在 GDM 筛查时和产后两个月通过 ELISA 测定白细胞介素-6 水平。
GDM 组妇女的白细胞介素-6 浓度明显高于对照组妇女（1.47±0.72 vs. 0.90±0.32pg/ml，p≤0.01）。在产后两个月时也得到了类似的结果，GDM 组妇女的 IL-6 水平仍然明显高于对照组妇女（1.88±0.85 vs. 1.41±0.87pg/ml，p≤0.05）。白细胞介素-6 浓度与两个时间点的 Matsuda 胰岛素敏感性指数显著相关（r=-0.60，p≤0.01 和 r=-0.34，p≤0.05）。Matsuda 胰岛素敏感性指数是 GDM 筛查时 IL-6 浓度的独立且显著的预测因子，解释了该变量的 35.6%（p≤0.0001）的方差。GDM 筛查时测量的白细胞介素-6 浓度是产后白细胞介素-6 浓度的独立且显著的预测因子，解释了 28.6%的方差（p≤0.001）。
这些结果表明，GDM 与肥胖水平无关，无论是在怀孕期间还是分娩后，都与升高的 IL-6 水平有关。
