École de Nutrition, l'Université Laval, Québec, QC G1V 0A6, Canada.
Centre Nutrition, Santé et Société (NUTRISS), l'Institut sur la Nutrition et les Aliments Fonctionnels (INAF), l'Université Laval, Québec, QC G1V 0A6, Canada.
Nutrients. 2022 Sep 27;14(19):3999. doi: 10.3390/nu14193999.
This study aimed to (1) characterize the variations in serum fructosamine across trimesters and according to pre-pregnancy BMI (ppBMI), and (2) examine associations between fructosamine and adiposity/metabolic markers (ppBMI, first-trimester adiposity, leptin, glucose homeostasis, and inflammation measurements) during pregnancy. Serum fructosamine, albumin, fasting glucose and insulin, leptin, adiponectin, interleukin-6 (IL-6), and C-reactive protein (CRP) concentrations were measured at each trimester. In the first trimester, subcutaneous (SAT) and visceral (VAT) adipose tissue thicknesses were estimated by ultrasound. In the 101 healthy pregnant individuals included (age: 32.2 ± 3.5 y.o.; ppBMI: 25.5 ± 5.5 kg/m2), fructosamine concentrations decreased during pregnancy whereas albumin-corrected fructosamine concentrations increased (p < 0.0001 for both). Notably, fructosamine concentrations were inversely associated with ppBMI, first-trimester SAT, VAT, and leptin (r = −0.55, r = −0.61, r = −0.48, r = −0.47, respectively; p < 0.0001 for all), first-trimester fasting insulin and HOMA-IR (r = −0.46, r = −0.46; p < 0.0001 for both), and first-trimester IL-6 (r = −0.38, p < 0.01). However, once corrected for albumin, most of the correlations lost strength. Once adjusted for ppBMI, fructosamine concentrations were positively associated with third-trimester fasting glucose and CRP (r = 0.24, r = 0.27; p < 0.05 for both). In conclusion, serum fructosamine is inversely associated with adiposity before and during pregnancy, with markers of glucose homeostasis and inflammation, but the latter associations are partially influenced by albumin concentrations and ppBMI.
(1) 描述血清果糖胺在妊娠期间各孕期的变化，并根据孕前 BMI（ppBMI）进行描述；(2) 研究妊娠期间血清果糖胺与肥胖/代谢标志物（ppBMI、孕早期肥胖、瘦素、葡萄糖稳态和炎症标志物）之间的相关性。在每个孕期均检测血清果糖胺、白蛋白、空腹血糖和胰岛素、瘦素、脂联素、白细胞介素-6（IL-6）和 C 反应蛋白（CRP）浓度。在孕早期，通过超声测量皮下（SAT）和内脏（VAT）脂肪组织厚度。在 101 名健康孕妇中（年龄：32.2 ± 3.5 岁；ppBMI：25.5 ± 5.5 kg/m2），果糖胺浓度在妊娠期间下降，而白蛋白校正后的果糖胺浓度升高（均<0.0001）。值得注意的是，果糖胺浓度与 ppBMI、孕早期 SAT、VAT 和瘦素呈负相关（r=-0.55、r=-0.61、r=-0.48、r=-0.47；均<0.0001），与孕早期空腹胰岛素和 HOMA-IR 呈负相关（r=-0.46、r=-0.46；均<0.0001），与孕早期 IL-6 呈负相关（r=-0.38，p<0.01）。然而，经白蛋白校正后，大多数相关性的强度降低。经 ppBMI 校正后，果糖胺浓度与孕晚期空腹血糖和 CRP 呈正相关（r=0.24、r=0.27；均<0.05）。结论：血清果糖胺与妊娠前和妊娠期间的肥胖呈负相关，与葡萄糖稳态和炎症标志物呈负相关，但后者的相关性部分受白蛋白浓度和 ppBMI 的影响。
