基于经验的阿片类药物使用和相关行为的亚型。
Empirically derived subtypes of opioid use and related behaviors.
机构信息
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
出版信息
Addiction. 2011 Jun;106(6):1146-54. doi: 10.1111/j.1360-0443.2011.03390.x. Epub 2011 Apr 28.
Abstract
AIMS
To identify and validate homogeneous subtypes of opioid use and related behaviors.
DESIGN
Family-based and case-control genetic studies of opioid and/or cocaine dependence.
SETTINGS
Clinical and general community samples from Connecticut, Massachusetts, Pennsylvania and South Carolina.
PARTICIPANTS
A total of 4061 individuals (2003 individuals from 835 families and 2058 unrelated individuals) recruited to participate in genetic studies.
MEASUREMENTS
The computer-assisted Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) was used to assess participants' demographics, medical history, substance use behaviors and disorders and other psychiatric disorders.
FINDINGS
Five homogeneous subtypes were identified, which differed on opioid-related measures, demographics and prevalence rates of substance use and psychiatric disorders. Heritability estimates for the two most severely affected subtypes exceeded 0.60.
CONCLUSIONS
An empirical approach based on opioid use and related behaviors can yield homogeneous subtypes that could be of value in gene finding for opioid dependence.
摘要
目的
确定和验证阿片类药物使用和相关行为的同质亚型。
设计
针对阿片类药物和/或可卡因依赖的基于家庭和病例对照的遗传研究。
地点
来自康涅狄格州、马萨诸塞州、宾夕法尼亚州和南卡罗来纳州的临床和一般社区样本。
参与者
共有 4061 名个体（835 个家庭中的 2003 名个体和 2058 名无关个体）被招募参加遗传研究。
测量方法
使用计算机辅助半结构化药物依赖和酒精障碍评估（SSADDA）来评估参与者的人口统计学、病史、物质使用行为和障碍以及其他精神障碍。
结果
确定了五个同质亚型，它们在阿片类药物相关措施、人口统计学以及物质使用和精神障碍的患病率方面存在差异。两个受影响最严重的亚型的遗传度估计值超过 0.60。
结论
基于阿片类药物使用和相关行为的实证方法可以产生同质亚型，这可能对阿片类药物依赖的基因发现有价值。
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