Sudo T, Tsubakimoto R, Miyamoto M, Bessho H, Kanazawa H, Yasuda C, Fukunishi K, Uchida T, Kawamura M, Kuyama T
Second Department of Surgery, Kinki University School of Medicine, Sayama, Japan.
Nihon Geka Hokan. 1990 Mar 1;59(2):105-15.
Total Pancreatectomy was performed under nembutal anesthesia in 16 adult mongrel dogs after a 24-hour fast, and the depancreatized dogs were given parenteral nutrition containing fat emulsion. Serum lipids, intravenous fat tolerance and post-heparin lipolytic activity were determined and liver biopsy was done to demonstrate the presence or absence of fatty liver. The animals were divided into three groups: group A (n = 6) received fat emulsion 1 g/kg/day; group B (n = 5), fat emulsion 2 g/kg/day; and group C (n = 5), no fat emulsion. Blood levels of cholesterol and phospholipid were increased in group B, while only a mild elevation of the blood triglyceride (TG) level was noted in group A. In group C, cholesterol and phospholipid levels were decreased, and hypoglycemia was liable to occur. The rate of disappearance of blood fat (K2) was decreased two weeks after surgery in group B, but there were no significant change in the other two groups. These findings suggest that if insulin is present, the administration of fat emulsion will not cause fatty liver.
在16只成年杂种犬禁食24小时后，用戊巴比妥麻醉实施全胰切除术，对胰腺切除的犬给予含脂肪乳剂的胃肠外营养。测定血清脂质、静脉脂肪耐量和肝素后脂解活性，并进行肝活检以证实是否存在脂肪肝。动物分为三组：A组（n = 6）每天接受1 g/kg的脂肪乳剂；B组（n = 5），每天2 g/kg的脂肪乳剂；C组（n = 5），不接受脂肪乳剂。B组血液中胆固醇和磷脂水平升高，而A组仅观察到血液甘油三酯（TG）水平轻度升高。C组胆固醇和磷脂水平降低，且易发生低血糖。B组术后两周血脂消失率（K2）降低，但其他两组无明显变化。这些发现表明，如果有胰岛素存在，给予脂肪乳剂不会导致脂肪肝。
