Relationship between the carbohydrate content of apoproteins of VLDL, IDL, and LDL and the plasma level of these lipoproteins in man. Short dietary effect.

A 1,500 Cal test meal was used to study in man the apoprotein B-carbohydrate content and composition of VLDL, IDL and LDL in relation to the variation of plasma lipids and lipoproteins and the VLDL-apoprotein composition. Three essential facts emerge from the study: (1) the mirror image (inverse significant correlation) between VLDL-apo B plasma concentration and N-acetylglucosamine content of apo B; (2) a reduction in total carbohydate concentration of VLDL- and LDL-apo B, 2--4 h after the test meal and a trend to a reduction in the mannose content; (3) a significant correlation between sialic acid and apoprotein B concentration in plasma LDL during fasting. The effect of diet and subsequent fasting on carbohydrates of lipoproteins and the consequence of such changes on lipoprotein uptake are briefly discussed.