General Intensive Care Unit, Raymond Poincaré hospital (AP-HP), University of Versailles SQY, 104 boulevard Raymond Poincaré, 92380, Garches, France,
Curr Infect Dis Rep. 2010 Sep;12(5):361-7. doi: 10.1007/s11908-010-0123-2.
Sepsis is a leading cause of death worldwide. The management of patients is primarily based on curing the infectious process with anti-infective drugs and/or surgical drainage. Simultaneously, treatment includes optimization of oxygen use by tissues via appropriate oxygen therapy and respiratory and hemodynamic management. At best, initiating appropriate anti-infective and symptomatic treatments should lead to patient improvement within a few hours. Activated protein C and hydrocortisone are the only two available adjunct therapies for sepsis. These treatments should optimally be started within 24 hours of the onset of shock. They should be initiated in those patients who did not adequately respond after 6 hours of optimal anti-infective and symptomatic treatments.
脓毒症是全球范围内主要的死亡原因。患者的治疗主要基于使用抗感染药物和/或手术引流来治疗感染过程。同时，治疗还包括通过适当的氧疗和呼吸及血液动力学管理来优化组织对氧气的利用。最好的情况下，在几小时内开始适当的抗感染和对症治疗应该会导致患者病情改善。活化蛋白 C 和氢化可的松是脓毒症唯一两种可用的辅助治疗方法。这些治疗方法应在休克发生后 24 小时内最佳开始。应在经过 6 小时最佳抗感染和对症治疗后仍未充分反应的患者中开始这些治疗。
