临床试验报告：疟疾有效疫苗的进展：RTS,S/ASO1B和RTS,S/ASO2A - Suppr

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Clinical Trials Report: Progress Toward an Effective Malaria Vaccine: RTS,S/ASO1B and RTS,S/ASO2A.

作者信息

Chen Lin H

机构信息

Mount Auburn Hospital, 330 Mount Auburn Street, Cambridge, MA, 02140, USA,

出版信息

Curr Infect Dis Rep. 2010 May;12(3):155-6. doi: 10.1007/s11908-010-0117-0.

DOI:10.1007/s11908-010-0117-0

PMID:21308523

Abstract

摘要

相似文献

Clinical Trials Report: Progress Toward an Effective Malaria Vaccine: RTS,S/ASO1B and RTS,S/ASO2A.临床试验报告：疟疾有效疫苗的进展：RTS,S/ASO1B和RTS,S/ASO2A

Curr Infect Dis Rep. 2010 May;12(3):155-6. doi: 10.1007/s11908-010-0117-0.

Mosquirix (RTS,S): a novel vaccine for the prevention of Plasmodium falciparum malaria.Mosquirix（RTS,S）：一种用于预防恶性疟原虫疟疾的新型疫苗。

Ann Pharmacother. 2012 Mar;46(3):384-93. doi: 10.1345/aph.1AQ634.

Duration of vaccine efficacy against malaria: 5th year of follow-up in children vaccinated with RTS,S/AS02 in Mozambique.疫苗预防疟疾的持续时间：在莫桑比克接种 RTS,S/AS02 的儿童进行的第 5 年随访。

Vaccine. 2014 Apr 17;32(19):2209-16. doi: 10.1016/j.vaccine.2014.02.042. Epub 2014 Mar 11.

Comprehensive Data Integration Approach to Assess Immune Responses and Correlates of RTS,S/AS01-Mediated Protection From Malaria Infection in Controlled Human Malaria Infection Trials.在受控人体疟疾感染试验中，采用综合数据整合方法评估RTS,S/AS01介导的对疟疾感染的免疫反应及相关因素。

Front Big Data. 2021 Jun 15;4:672460. doi: 10.3389/fdata.2021.672460. eCollection 2021.

The RTS,S malaria vaccine.RTS,S 疟疾疫苗。

Vaccine. 2010 Jul 12;28(31):4880-94. doi: 10.1016/j.vaccine.2010.05.033. Epub 2010 May 27.

Clinical development of RTS,S/AS malaria vaccine: a systematic review of clinical Phase I-III trials.RTS,S/AS疟疾疫苗的临床开发：对I-III期临床试验的系统评价

Future Microbiol. 2015;10(10):1553-78. doi: 10.2217/fmb.15.90. Epub 2015 Oct 6.

From the circumsporozoite protein to the RTS, S/AS candidate vaccine.从环子孢子蛋白到RTS，S/AS候选疫苗。

Hum Vaccin. 2010 Jan;6(1):90-6. doi: 10.4161/hv.6.1.9677. Epub 2010 Jan 30.

Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial.肯尼亚和坦桑尼亚 5-17 月龄儿童中 RTS,S/AS01E 疟疾疫苗的有效性及抗环子孢子蛋白抗体滴度和保护作用的探索性分析：一项随机对照试验。

Lancet Infect Dis. 2011 Feb;11(2):102-9. doi: 10.1016/S1473-3099(10)70262-0. Epub 2011 Jan 13.

Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection.恶性疟原虫疟疾疫苗RTS,S/AS01B和RTS,S/AS02A在未感染疟疾成年人中的随机、双盲、2a期试验：安全性、有效性及保护的免疫相关因素

J Infect Dis. 2009 Aug 1;200(3):337-46. doi: 10.1086/600120.

Sequential Phase 1 and Phase 2 randomized, controlled trials of the safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine antigens RTS,S and TRAP formulated with AS02 Adjuvant System in healthy, malaria naïve adults.在未感染过疟疾的健康成年人中，对与AS02佐剂系统配制的联合红细胞前期疫苗抗原RTS,S和TRAP的安全性、免疫原性和有效性进行的1期和2期序贯随机对照试验。

Vaccine. 2014 Nov 20;32(49):6683-91. doi: 10.1016/j.vaccine.2014.06.033. Epub 2014 Jun 18.

本文引用的文献

The development of the RTS,S malaria vaccine candidate: challenges and lessons.疟疾候选疫苗RTS,S的研发：挑战与经验教训

Parasite Immunol. 2009 Sep;31(9):492-500. doi: 10.1111/j.1365-3024.2009.01143.x.

Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area.在高疟疾传播地区对成人进行RTS,S/AS02A和RTS,S/AS01B评估。

PLoS One. 2009 Jul 31;4(7):e6465. doi: 10.1371/journal.pone.0006465.

Long-term safety and efficacy of the RTS,S/AS02A malaria vaccine in Mozambican children.RTS,S/AS02A疟疾疫苗在莫桑比克儿童中的长期安全性和有效性

J Infect Dis. 2009 Aug 1;200(3):329-36. doi: 10.1086/600119.

Safety and immunogenicity of the RTS,S/AS02A candidate malaria vaccine in children aged 1-4 in Mozambique.莫桑比克1至4岁儿童中RTS,S/AS02A疟疾候选疫苗的安全性和免疫原性。

Trop Med Int Health. 2007 Jan;12(1):37-46. doi: 10.1111/j.1365-3156.2006.01754.x.

Phase 1 safety and immunogenicity trial of malaria vaccine RTS,S/AS02A in adults in a hyperendemic region of western Kenya.疟疾疫苗RTS,S/AS02A在肯尼亚西部高度流行地区成年人中的1期安全性和免疫原性试验。

Am J Trop Med Hyg. 2006 Jul;75(1):166-70.

Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trial.RTS,S/AS02A疟疾疫苗预防莫桑比克儿童恶性疟原虫病的保护期：一项随机对照试验的单盲延长随访

Lancet. 2005 Dec 10;366(9502):2012-8. doi: 10.1016/S0140-6736(05)67669-6.

Safety and immunogenicty of RTS,S/AS02A candidate malaria vaccine in Gambian children.RTS,S/AS02A候选疟疾疫苗在冈比亚儿童中的安全性和免疫原性。

Vaccine. 2005 Jul 14;23(32):4148-57. doi: 10.1016/j.vaccine.2005.03.019. Epub 2005 Apr 15.

Protective immunity induced with malaria vaccine, RTS,S, is linked to Plasmodium falciparum circumsporozoite protein-specific CD4+ and CD8+ T cells producing IFN-gamma.疟疾疫苗RTS,S诱导产生的保护性免疫与产生γ干扰素的恶性疟原虫环子孢子蛋白特异性CD4+和CD8+ T细胞有关。

J Immunol. 2003 Dec 15;171(12):6961-7. doi: 10.4049/jimmunol.171.12.6961.

Development of RTS,S/AS02: a purified subunit-based malaria vaccine candidate formulated with a novel adjuvant.RTS,S/AS02的研发：一种与新型佐剂配制的基于亚单位的纯化疟疾候选疫苗。

Expert Rev Vaccines. 2003 Apr;2(2):231-8. doi: 10.1586/14760584.2.2.231.

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