Department of Otolaryngology, Emory University School of Medicine, 1365-A Clifton Road NE, Atlanta, GA, 30322, USA,
Curr Infect Dis Rep. 2010 May;12(3):217-24. doi: 10.1007/s11908-010-0095-2.
Aspergillus is a chronic colonizer as well as a nidus of infection in the sinuses and ears. In the sinuses, the severity of the disease is classified by the invasiveness of the infection. Invasive fungal sinusitis varies in its presentation based upon the infective organism and shows reduced morbidity if identified early, which requires a high index of suspicion. Allergic fungal sinusitis was recently further classified using a radiologic staging system and was proven to have symptomatic improvement with the concomitant use of surgery and immunotherapy. Finally, fungal ball appears to be a chronic problem that is usually cured with surgery. Aspergillus in the ear is a relatively common problem often related to prolonged antibiotic use and almost always successfully treated with topical antifungals.
曲霉菌是鼻窦和耳部慢性定植菌和感染灶。在鼻窦,疾病严重程度根据感染侵袭性进行分类。侵袭性真菌性鼻窦炎根据感染病原体表现不同,早期发现可降低发病率,这需要高度怀疑。变应性真菌性鼻窦炎最近采用放射学分期系统进一步分类,证实手术和免疫治疗联合应用可改善症状。最后,真菌球似乎是一个慢性问题,通常通过手术治愈。耳部曲霉菌是一个相对常见的问题,常与长期使用抗生素有关,几乎都可以用局部抗真菌药物成功治疗。