Korsak Z, Sokal J A, Wasiela T, Swiercz R
Department of Toxicity Evaluation, Nofer Institute of Occupational Medicine, Lodz, Poland.
Pol J Occup Med. 1990;3(2):221-6.
The effect of exposure to particular xylene isomers at a concentration of 3000 ppm on rotarod performance in rats and the respiratory rate in mice was investigated. Rotarod performance was tested in rats immediately after termination of a 6-hour exposure, and the respiratory rate in mice was recorded during a short 6 minute exposure to individual xylene isomers. In both rats and mice the toxic effects of exposure to ortho- and meta-xylene were more pronounced than that of para-xylene.
研究了大鼠在浓度为3000 ppm的特定二甲苯异构体暴露下对转棒试验表现以及小鼠呼吸频率的影响。在6小时暴露结束后立即对大鼠进行转棒试验，在小鼠短时间暴露于各个二甲苯异构体的6分钟内记录其呼吸频率。在大鼠和小鼠中，暴露于邻二甲苯和间二甲苯的毒性作用比对二甲苯更明显。
