Ege T, Gur O, Karadag C H, Duran E
Department of Cardiovascular Surgery, Trakya University Medical Faculty, Edirne, Turkey.
J Int Med Res. 2010 Sep-Oct;38(5):1759-63. doi: 10.1177/147323001003800521.
This study assessed the efficacy of iloprost in relieving vasospasm in coronary artery bypass grafts. Radial artery (RA), left internal thoracic artery (LITA) and saphenous vein (SV) grafts were taken from 20 patients (13 men and seven women, mean age 63.8 years [range 48-74 years]) scheduled to undergo coronary artery bypass grafting. Ten 3 mm vascular rings were cut from each graft and kept under tension for at least 60 min. They were kept alive with 37 degrees C oxygenated Krebs solution. Smooth muscle contraction was achieved with phenylephrine before iloprost was administered every 2 min, starting at a concentration of 10(-9) mol/l and increasing in logarithmic increments to a concentration of 10(-5) mol/l. The vasodilation response to iloprost started in all samples at a concentration of 10(-9) mol/l and increased with each incremental increase in iloprost concentration up to 10(-5) mol/l. These data suggest that local administration of iloprost has a role in relieving graft vasospasm during harvesting and preparation for coronary artery bypass grafting.
本研究评估了伊洛前列素在缓解冠状动脉旁路移植术中血管痉挛方面的疗效。从20例计划接受冠状动脉旁路移植术的患者（13例男性和7例女性，平均年龄63.8岁[范围48 - 74岁]）获取桡动脉（RA）、左内乳动脉（LITA）和大隐静脉（SV）移植物。从每个移植物上切下10个3毫米的血管环，并使其保持张力至少60分钟。用37摄氏度的含氧克雷布斯溶液使其保持存活状态。在每2分钟给予伊洛前列素之前，先用去氧肾上腺素引起平滑肌收缩，起始浓度为10^(-9)摩尔/升，并以对数增量增加至10^(-5)摩尔/升。所有样本在伊洛前列素浓度为10^(-9)摩尔/升时开始出现血管舒张反应，并随着伊洛前列素浓度递增至10^(-5)摩尔/升而增强。这些数据表明，在冠状动脉旁路移植术的获取和准备过程中，局部应用伊洛前列素在缓解移植物血管痉挛方面具有作用。
