小细胞肺癌合并低钠血症的临床特征及预后分析
[Clinical features and prognosis analysis of small-cell lung cancer complicated with hyponatremia].
作者信息
Ma Fang, Liu Xianling, Hu Chunhong, Huang Ming
机构信息
Department of Medical Oncology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Jan;36(1):64-7. doi: 10.3969/j.issn.1672-7347.2011.01.010.
OBJECTIVE
To evaluate the clinical features and prognosis of small-cell lung cancer (SCLC) complicated with hyponatremia.
METHODS
The clinical data of 158 patients with SCLC of the Second Xiangya Hospital from January 2000 to December 2007 were studied retrospectively.
RESULTS
The incidence rate of hyponatremia in SCLC was 42.4%(67/158). The median survival time was 7.6 months in patients with subnormal serum sodium, and 14.1 months in patients with normal values. There was significantly different between 2 groups (P<0.001). The patients who did not fully regain normal values of serum sodium, had poorer survival (6.2 months) compared with the patients with normal serum sodium (10.3 months, P=0.044).
CONCLUSION
The incidence rate of hyponatremia in SCLC is high. The prognosis of SCLC with hyponatremia is very poor, especially in those who can not regain normal values of serum sodium after the treatment. So diagnosis and treatment at early stage are very important.
目的
评估小细胞肺癌（SCLC）合并低钠血症的临床特征及预后。
方法
回顾性分析2000年1月至2007年12月在中南大学湘雅二医院收治的158例SCLC患者的临床资料。
结果
SCLC患者低钠血症发生率为42.4%（67/158）。血钠异常患者的中位生存时间为7.6个月，血钠正常患者为14.1个月。两组间差异有统计学意义（P<0.001）。血钠未完全恢复正常的患者生存情况较差（6.2个月），而血钠正常患者生存时间为10.3个月（P=0.044）。
结论
SCLC患者低钠血症发生率高。合并低钠血症的SCLC患者预后很差，尤其是治疗后血钠不能恢复正常的患者。因此早期诊断和治疗非常重要。
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