Gross A J, Steinberg S M, Reilly J G, Bliss D P, Brennan J, Le P T, Simmons A, Phelps R, Mulshine J L, Ihde D C
National Cancer Institute-Navy Medical Oncology Branch, Maryland 20889-5105.
Cancer Res. 1993 Jan 1;53(1):67-74.
Patients with lung cancer (n = 263) were studied to determine the relationship among ectopic production of atrial natriuretic factors (ANF) and arginine vasopressin (AVP), serum sodium, and patient outcome. Of 133, 21 (16%) patients with small cell lung cancer (SCLC) had hyponatremia (serum sodium, < 130 mmol/liter), compared to none of 130 (0%) patients with non-small cell lung cancer (P < 0.0001). Patients with extensive-stage SCLC and hyponatremia had shorter survival than patients with extensive stage SCLC and normal serum sodium values (P = 0.012). Of the 11 hyponatremic patients with SCLC and tumor cell lines available for study, 9 produced ANF mRNA, 7 of 11 produced AVP mRNA, and 5 of 11 produced both ANF mRNA and AVP mRNA. All 11 cell lines produced either ANF mRNA and ANF peptide or AVP mRNA and AVP peptide, or both. The quantity of AVP peptide in the tumor cell lines was more closely associated with hyponatremia in the patients (P = 0.0026, r2 = 0.28) than was the production of ANF peptide (P = 0.066, r2 = 0.12), although neither association was strong. All tumor cell lines studied from SCLC patients with hyponatremia produce ANF and/or AVP mRNA and peptides.
对263例肺癌患者进行了研究，以确定心房利钠因子（ANF）和精氨酸加压素（AVP）的异位产生、血清钠与患者预后之间的关系。在133例小细胞肺癌（SCLC）患者中，21例（16%）出现低钠血症（血清钠<130 mmol/L），而130例非小细胞肺癌患者中无一例出现低钠血症（P<0.0001）。广泛期SCLC合并低钠血症的患者生存期短于广泛期SCLC且血清钠值正常的患者（P = 0.012）。在11例有肿瘤细胞系可供研究的SCLC低钠血症患者中，9例产生ANF mRNA，11例中的7例产生AVP mRNA，11例中的5例同时产生ANF mRNA和AVP mRNA。所有11个细胞系均产生ANF mRNA和ANF肽，或AVP mRNA和AVP肽，或两者皆有。肿瘤细胞系中AVP肽的量与患者低钠血症的相关性比ANF肽的产生更密切（P = 0.0026，r2 = 0.28），而ANF肽的产生与低钠血症的相关性为P = 0.066（r2 = 0.12），尽管两者的相关性都不强。对所有来自SCLC低钠血症患者的肿瘤细胞系研究发现，它们均产生ANF和/或AVP mRNA及肽。
