Division of Alcohol and Drug Abuse, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
Am J Addict. 2011 Mar-Apr;20(2):100-5. doi: 10.1111/j.1521-0391.2010.00117.x. Epub 2011 Feb 1.
In this exploratory analysis, we assessed the effect of drug use among social-network members on recovery from drug dependence in patients with co-occurring bipolar disorder. Patients (n = 57) enrolled in a group therapy study completed assessments over 15 months. Patients with zero to one drug users in their social networks at intake had few days of drug use during treatment and follow-up, whereas those with ≥ 2 drug users had significantly more days of drug use. Multivariate analysis showed that patients who consistently named multiple drug users in their social networks had a marked increase in drug use over 15 months, while those who never or occasionally named multiple drug users had a small decline in drug use over time. Multiple drug users in social networks of treatment-seeking drug-dependent patients with co-occurring bipolar disorder may indicate poor drug use outcomes; efforts to reduce the association with drug users may be useful. This clinical trial has been registered in a public trials registry at clinicaltrials.gov (identifier is NCT00227838).
在这项探索性分析中，我们评估了社交网络成员中的药物使用对共病双相情感障碍患者药物依赖康复的影响。参与小组治疗研究的患者（n=57）在 15 个月内完成了评估。在入组时社交网络中零到一个药物使用者的患者在治疗和随访期间的药物使用天数很少，而有≥2 个药物使用者的患者药物使用天数明显更多。多变量分析显示，在 15 个月内持续在社交网络中提到多个药物使用者的患者药物使用量明显增加，而那些从未或偶尔提到多个药物使用者的患者药物使用量随时间逐渐减少。共病双相情感障碍的治疗寻求药物依赖患者的社交网络中的多个药物使用者可能预示着较差的药物使用结果；减少与药物使用者的关联可能会有所帮助。这项临床试验已在 clinicaltrials.gov（标识符为 NCT00227838）的公共试验注册处注册。
