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[慢性肾衰竭的治疗:必需氨基酸补充饮食的效果]

[Treatment of chronic renal failure: effects of a supplemented diet with essential amino acids].

作者信息

Muñoz E, Aicardi V, Morales A, Hirsch S, Petermann M, Bunout D, Morales J

机构信息

Departamento de Medicina, Facultad de Medicina, Universidad de Chile, Santiago.

出版信息

Rev Med Chil. 1990 Mar;118(3):259-63.

PMID:2131504
Abstract

We evaluated the results of essential amino acids supplementation added to a protein restricted diet (0.6 g/kg/day) in patients with advanced renal failure (creatinine clearance under 20 ml/min). A diet containing food with high biologic value was used as control. Diets were tested during 7 months. Anthropometric and nutritional (serum albumin and transferrin) values were normal in both groups both at the beginning and at the end of the treatment period. A slight increase in weight in the natural diet group and in serum phosphorus level in the amino acid supplemented group was observed. Two patients in each group required chronic dialysis, renal function remaining stable in the rest. We conclude that both forms of diet supplementation were effective in preserving nutritional status possibly in delaying deterioration of renal function in patients with advanced renal failure.

摘要

我们评估了在晚期肾衰竭(肌酐清除率低于20 ml/分钟)患者中,在蛋白质限制饮食(0.6 g/kg/天)基础上补充必需氨基酸的效果。将含有高生物价值食物的饮食作为对照。饮食测试持续了7个月。在治疗期开始和结束时,两组的人体测量和营养指标(血清白蛋白和转铁蛋白)均正常。观察到天然饮食组体重略有增加,氨基酸补充组血清磷水平有所上升。每组有两名患者需要长期透析,其余患者肾功能保持稳定。我们得出结论,两种饮食补充方式在维持营养状况方面均有效,可能还有助于延缓晚期肾衰竭患者肾功能的恶化。

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