Notch 更进一步：Jagged1 在骨转移中。
One NOTCH Further: Jagged 1 in Bone Metastasis.
机构信息
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Cancer Cell. 2011 Feb 15;19(2):159-61. doi: 10.1016/j.ccr.2011.01.043.
PMID:21316596
Abstract
The outgrowth of metastatic cells to bone depends on the interaction between multiple intrinsic and host factors. In this issue of Cancer Cell, Sethi and colleagues report Notch signaling in bone cells as responsible for promoting this outgrowth and provide evidence for a beneficial treatment effect of NOTCH inhibitors.
摘要
转移细胞在骨骼中的生长依赖于多种内在和宿主因素之间的相互作用。在本期《癌细胞》杂志中，Sethi 及其同事报道了骨细胞中的 Notch 信号通路在促进这种生长中的作用，并为 NOTCH 抑制剂的有益治疗效果提供了证据。
Zotero 插件