Çizmecioğlu Filiz Mine, Etiler Nilay, Görmüş Uzay, Hamzaoğlu Onur, Hatun Şükrü
Division of Endocrinology and Diabetes, Department of Pediatrics, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey.
J Clin Res Pediatr Endocrinol. 2008;1(2):89-96. doi: 10.4008/jcrpe.v1i2.43. Epub 2008 Nov 5.
To determine the prevalence of vitamin D hypovitaminosis among obese and overweight schoolchildren.
A cross-sectional population based sample.
In a cross-sectional study, 301 students (177 girls and 124 boys) aged 11-19 years were selected by multistage stratified sampling design. Subjects were classified according to their body mass index as obese, overweight and normal. Serum 25-hydroxyvitamin D (25-OHD), intact parathyroid hormone (iPTH) and alkaline phosphatase (ALP) were measured in late winter months. Vitamin D deficiency was defined as a 25-OHD 20 ng/ml.
The prevalence of hypovitaminosis D was found as 65% in all students. Vitamin D deficiency was found in 12% and insufficiency in 53% of all students. Vitamin D deficiency in female students was about two times more common than in males. In obese and overweight schoolchildren with hypovitaminosis D, serum 25-OHD levels decreased as BMI increased. There were no correlations between serum 25-OHD and ALP and iPTH levels.
Vitamin D deficiency and insufficiency are common in obese and overweight schoolchildren, especially in girls. Obesity could be a risk factor in terms of hypovitaminosis D in adolescents. Vitamin D supplementation should be administered particularly to adolescent girls.
确定肥胖和超重学童中维生素D缺乏症的患病率。
基于人群的横断面样本。
在一项横断面研究中，通过多阶段分层抽样设计选取了301名年龄在11至19岁的学生（177名女生和124名男生）。根据体重指数将受试者分为肥胖、超重和正常三类。在冬末测量血清25-羟维生素D（25-OHD）、完整甲状旁腺激素（iPTH）和碱性磷酸酶（ALP）。维生素D缺乏定义为25-OHD<20 ng/ml。
所有学生中维生素D缺乏症的患病率为65%。所有学生中维生素D缺乏的比例为12%，不足的比例为53%。女生维生素D缺乏的情况比男生普遍约两倍。在患有维生素D缺乏症的肥胖和超重学童中，血清25-OHD水平随BMI增加而降低。血清25-OHD与ALP和iPTH水平之间无相关性。
维生素D缺乏和不足在肥胖和超重学童中很常见，尤其是在女孩中。肥胖可能是青少年维生素D缺乏症的一个危险因素。应特别对青春期女孩进行维生素D补充。
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