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Expression status of the autophagy-regulatory gene ATG6/BECN1 in ERBB2-positive breast carcinomas: bypassing ERBB2-induced oncogenic senescence to regulate the efficacy of ERBB2-targeted therapies.

作者信息

Vazquez-Martin Alejandro, Cufí Silvia, Oliveras-Ferraros Cristina, Martin-Castillo Begoña, Del Barco Sonia, López-Bonet Eugeni, Menendez Javier A

出版信息

Genes Chromosomes Cancer. 2011 Apr;50(4):284-90. doi: 10.1002/gcc.20846. Epub 2011 Jan 3.

DOI:10.1002/gcc.20846
PMID:21319263
Abstract
摘要

相似文献

1
Expression status of the autophagy-regulatory gene ATG6/BECN1 in ERBB2-positive breast carcinomas: bypassing ERBB2-induced oncogenic senescence to regulate the efficacy of ERBB2-targeted therapies.自噬调节基因ATG6/BECN1在ERBB2阳性乳腺癌中的表达状态：绕过ERBB2诱导的致癌衰老以调节ERBB2靶向治疗的疗效
Genes Chromosomes Cancer. 2011 Apr;50(4):284-90. doi: 10.1002/gcc.20846. Epub 2011 Jan 3.
2
ERBB2 phosphorylation and trastuzumab sensitivity of breast cancer cell lines.乳腺癌细胞系的ERBB2磷酸化与曲妥珠单抗敏感性
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3
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Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin.在ERBB2扩增的乳腺癌中，RALT/MIG-6表达缺失会增强ErbB-2致癌能力并导致对赫赛汀产生耐药性。
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p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy.p130Cas支架蛋白通过改变乳腺癌细胞对自噬的敏感性来调节ErbB2的稳定性。
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Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1.热休克蛋白90抑制剂17-AAG可降低ErbB2水平，并抑制曲妥珠单抗耐药乳腺癌细胞系JIMT-1的增殖。
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Oncogenic alterations in ERBB2/HER2 represent potential therapeutic targets across tumors from diverse anatomic sites of origin.ERBB2/HER2中的致癌改变代表了来自不同解剖起源部位肿瘤的潜在治疗靶点。
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Will single-time tumor profiling and a "guilt by association" approach allow us to outsmart HER2-positive breast cancer?单次肿瘤分析和“关联定罪”方法能让我们在应对HER2阳性乳腺癌时技高一筹吗？
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引用本文的文献

1
Autophagy and Apoptotic Crosstalk: Mechanism of Therapeutic Resistance in HER2-Positive Breast Cancer.自噬与凋亡的相互作用：HER2阳性乳腺癌治疗耐药的机制
Breast Cancer (Auckl). 2016 Mar 13;10:13-23. doi: 10.4137/BCBCR.S32791. eCollection 2016.
2
Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids.自噬可保护HER2过表达的乳腺肿瘤球体免受曲妥珠单抗诱导的细胞毒性作用。
PLoS One. 2015 Sep 11;10(9):e0137920. doi: 10.1371/journal.pone.0137920. eCollection 2015.
3
Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors.
HUNK对细胞存活的调控介导了乳腺癌对HER2抑制剂的耐药性。
Breast Cancer Res Treat. 2015 Jan;149(1):91-8. doi: 10.1007/s10549-014-3227-9. Epub 2014 Dec 17.
4
Low expression of Beclin 1 and elevated expression of HIF-1α refine distant metastasis risk and predict poor prognosis of ER-positive, HER2-negative breast cancer.Beclin 1 低表达和 HIF-1α 高表达可细化 ER 阳性、HER2 阴性乳腺癌的远处转移风险，并预测不良预后。
Med Oncol. 2013 Mar;30(1):355. doi: 10.1007/s12032-012-0355-0. Epub 2013 Feb 14.
5
Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment.自噬相关基因12（ATG12）是对HER2靶向治疗原发性耐药的新决定因素：自噬相互作用组转录组分析在指导乳腺癌治疗中的应用
Oncotarget. 2012 Dec;3(12):1600-14. doi: 10.18632/oncotarget.742.
6
Autophagy and endocrine resistance in breast cancer.自噬与乳腺癌内分泌耐药。
Expert Rev Anticancer Ther. 2011 Aug;11(8):1283-94. doi: 10.1586/era.11.111.
7
Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions.将氯喹和二甲双胍重新定位以消除癌前病变中的癌症干细胞特征。
Drug Resist Updat. 2011 Aug-Oct;14(4-5):212-23. doi: 10.1016/j.drup.2011.04.003. Epub 2011 May 19.