偏头痛患者皮质下兴奋过度：一项高频振荡研究。
Subcortical hyperexcitability in migraineurs: a high-frequency oscillation study.
机构信息
Department of Neurology, Taipei Municipal Gandau Hospital, and Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan.
出版信息
Can J Neurol Sci. 2011 Mar;38(2):309-16. doi: 10.1017/s0317167100011525.
OBJECTIVE
An abnormal central nervous system excitability level was found in patients with migraine. Whether it is hyper- or hypo-excitable is still debated. This study aimed to compare the somatosensory high-frequency oscillations (HFOs), which reflected subcortical excitability (early phase) and intracortical inhibition (late phase), between patients with migraine and control subjects.
METHODS
HFOs were recorded from C3'-Fz, using a 500-1000 Hz frequency filter after stimulation at right median nerves at the wrists, and divided into early and late phases based on the N20 peak. Fifty-nine untreated patients (n=24 during ictal period; n=35, interictal) and 22 controls finished the study.
RESULTS
In early HFOs, patients both during ictal and interictal periods had higher maximal amplitudes (p=0.039) and area-under-curve (p=0.029) than those of the controls. Regarding the late HFOs, there were no significant differences among these groups.
CONCLUSION
Our study suggests a hyper-excitable state in the subcortical regions in patients with migraine both during interictal and ictal periods.
目的
偏头痛患者的中枢神经系统兴奋性水平异常。其是兴奋过高还是过低仍存在争议。本研究旨在比较偏头痛患者和对照组之间的体感高频振荡（HFOs），这反映了皮质下兴奋性（早期）和皮质内抑制（晚期）。
方法
使用腕部正中神经刺激，在 C3'-Fz 处记录 HFOs，使用 500-1000 Hz 频率滤波器进行滤波，并根据 N20 峰将其分为早期和晚期。59 名未经治疗的患者（发作期 24 名；间歇期 35 名）和 22 名对照者完成了研究。
结果
在早期 HFOs 中，发作期和间歇期患者的最大振幅（p=0.039）和曲线下面积（p=0.029）均高于对照组。至于晚期 HFOs，这些组之间没有显著差异。
结论
我们的研究表明，偏头痛患者在发作期和间歇期的皮质下区域均处于超兴奋状态。
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