偏头痛患者的体感诱发性高频振荡

Somatosensory evoked high-frequency oscillations in migraine patients.

作者信息

Sakuma Kenji, Takeshima Takao, Ishizaki Kumiko, Nakashima Kenji

机构信息

Section of Environment and Health Science, Department of Biological Regulation, School of Health Sciences, Faculty of Medicine, Tottori University, 86 Nishimachi, Yonago, Japan.

出版信息

Clin Neurophysiol. 2004 Aug;115(8):1857-62. doi: 10.1016/j.clinph.2004.03.011.

DOI:10.1016/j.clinph.2004.03.011

PMID:15261864

Abstract

OBJECTIVE

To explore additional evidence concerning generators of somatosensory evoked high-frequency oscillations (HFOs).

METHODS

We recorded HFOs in migraine patients. Subjects were 19 healthy normal subjects and 19 migraineurs. Electrical stimuli were delivered alternately to the right and left median nerves at their wrists. EEGs were recorded from C3'-Fz, C4'-Fz, Erb1-Erb2, Erb2-Erb1 and Cv6-Fz using a 0.3 Hz low-frequency filter and a 3000 Hz high-frequency filter. Responses to 5000 stimuli were averaged. For separation of HFOs from underlying N20, the digitized wide-band signals were digitally bandpass filtered (400-800 Hz) and averaged.

RESULTS

There were no significant differences in peak latencies and amplitudes for N9, N13, N20 and P25 components between normal controls and migraineurs. Root-mean-square amplitudes for HFOs in migraineurs were significantly diminished compared with normal controls.

CONCLUSIONS

A diminished inhibitory mechanism in the somatosensory system may exist in migraineurs. It remains to determine what cell populations contribute to generating HFOs.

SIGNIFICANCE

This indicates that there is a dysfunction in cortical information processing in the somatosensory cortex of migraineurs.

摘要

目的

探索有关体感诱发性高频振荡（HFOs）产生源的更多证据。

方法

我们记录了偏头痛患者的HFOs。受试者包括19名健康正常人和19名偏头痛患者。在手腕处交替向右侧和左侧正中神经施加电刺激。使用0.3Hz低频滤波器和3000Hz高频滤波器，从C3'-Fz、C4'-Fz、Erb1-Erb2、Erb2-Erb1和Cv6-Fz记录脑电图。对5000次刺激的反应进行平均。为了从潜在的N20中分离出HFOs，对数字化宽带信号进行数字带通滤波（400-800Hz）并平均。