Mantz J, Blanchot G, Marty J, Farinotti R, Trouvin J H, Hazebroucq J, Desmonts J M
Department of Anesthesiology, Hospital Bichat, Paris, France.
J Cardiothorac Anesth. 1990 Oct;4(5):577-81. doi: 10.1016/0888-6296(90)90407-7.
Cardiopulmonary bypass (CPB) has been reported to alter the disposition of numerous drugs and consequently to modify their plasma levels. The present study was designed to delineate the time course of acebutolol (a cardioselective beta-blocker) and diacetolol (its main metabolite) plasma levels in seven patients undergoing myocardial revascularization with hypothermic CPB. All patients were given oral acebutolol twice daily until 3 hours before surgery. Initiation of CPB produced an immediate and significant, but transient, decrease in acebutolol and diacetolol plasma concentrations. Cessation of CPB was not associated with an increase in plasma beta-blocker levels. It is concluded that CPB does not induce major alterations in the time course of acebutolol and diacetolol plasma concentrations.
据报道，体外循环（CPB）会改变多种药物的处置方式，从而改变其血浆水平。本研究旨在描绘7例接受低温CPB心肌血运重建术患者的醋丁洛尔（一种心脏选择性β受体阻滞剂）和双醋洛尔（其主要代谢产物）血浆水平的时间进程。所有患者在手术前3小时每天口服醋丁洛尔两次。CPB开始时，醋丁洛尔和双醋洛尔的血浆浓度立即显著但短暂降低。CPB停止后，血浆β受体阻滞剂水平并未升高。结论是CPB不会引起醋丁洛尔和双醋洛尔血浆浓度时间进程的重大改变。
