Halim Ahmad Sukari, Khoo Teng Lye, Mohd Yussof Shah Jumaat
Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Indian J Plast Surg. 2010 Sep;43(Suppl):S23-8. doi: 10.4103/0970-0358.70712.
The current trend of burn wound care has shifted to more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. This has demanded the emergence of various skin substitutes in the management of acute burn injury as well as post burn reconstructions. Skin substitutes have important roles in the treatment of deep dermal and full thickness wounds of various aetiologies. At present, there is no ideal substitute in the market. Skin substitutes can be divided into two main classes, namely, biological and synthetic substitutes. The biological skin substitutes have a more intact extracellular matrix structure, while the synthetic skin substitutes can be synthesised on demand and can be modulated for specific purposes. Each class has its advantages and disadvantages. The biological skin substitutes may allow the construction of a more natural new dermis and allow excellent re-epithelialisation characteristics due to the presence of a basement membrane. Synthetic skin substitutes demonstrate the advantages of increase control over scaffold composition. The ultimate goal is to achieve an ideal skin substitute that provides an effective and scar-free wound healing.
当前烧伤创面护理的趋势已转向更全面的方法，以改善愈合后烧伤创面的长期形态和功能以及生活质量。这就要求在急性烧伤损伤的处理以及烧伤后重建中出现各种皮肤替代物。皮肤替代物在治疗各种病因的深度真皮和全层伤口中发挥着重要作用。目前，市场上没有理想的替代品。皮肤替代物可分为两大类，即生物替代品和合成替代品。生物皮肤替代物具有更完整的细胞外基质结构，而合成皮肤替代物可以按需合成，并可针对特定目的进行调节。每一类都有其优缺点。生物皮肤替代物可能允许构建更自然的新真皮，并由于存在基底膜而具有出色的再上皮化特性。合成皮肤替代物显示出对支架组成的控制增加的优点。最终目标是实现一种理想的皮肤替代物，提供有效且无瘢痕的伤口愈合。
