Bayona González A, López Cámara V, Gómez Castellanos A
Universidad Nacional Autónoma de Mexico (UNAM), Ciudad de Mexico.
Pract Odontol. 1990 Jul;11(7):37-9, 42-3, 45-6.
Caries prevention with lactic bacteria. (Final results of a dental caries clinical trial using heat killed lactic bacteria [streptococci and lactobacilli] orally.) The results of a dental caries clinical trial in 245 seven-year-old children are reported. Chewable tablets of two different types were prepared: A) Containing pyridoxine (Vit. B6) and heat killed lactic bacteria. B) Placebo tablets with pyridoxine only. They were randomly given once a week for 16 weeks to experimental and control groups respectively. Four evaluation surveys were conducted during 24 months of follow up, using the "Decay, Missing, Filled, Surfaces" index (DMFS) for the clinical evaluation of the permanent teeth. A consistent reduction in the incidence of dental caries in the experimental group was observed in all 4 surveys. After 2 years of follow up a 42% reduction in the incidence rate of dental caries was observed in the experimental group compared to the control group. Summary tables and discussion of the clinical evaluation surveys are given. The potential use of these clinical findings as support for a future dental caries vaccine evaluation project is proposed.
乳酸菌预防龋齿。（一项使用口服热灭活乳酸菌（链球菌和乳杆菌）的龋齿临床试验的最终结果）报告了一项针对245名7岁儿童的龋齿临床试验结果。制备了两种不同类型的咀嚼片：A）含有吡哆醇（维生素B6）和热灭活乳酸菌。B）仅含吡哆醇的安慰剂片。分别每周随机给实验组和对照组服用一次，持续16周。在24个月的随访期间进行了四次评估调查，使用“龋、失、补、面”指数（DMFS）对恒牙进行临床评估。在所有4次调查中，实验组的龋齿发病率均持续降低。随访2年后，实验组的龋齿发病率与对照组相比降低了42%。给出了临床评估调查的汇总表和讨论。提出了将这些临床发现作为未来龋齿疫苗评估项目支持依据的潜在用途。
