Department of Pathology, AMC-UvA, Amsterdam, The Netherlands.
Immunotherapy. 2011 Feb;3(2):147-51. doi: 10.2217/imt.10.102.
Autoimmune diseases are a group of maladies in which the patient's immune homeostasis becomes so deregulated that it mounts a destructive attack against the hosts tissues. Such diseases are characterized by an activation of autoreactive T and B cells and are associated, in some cases, with the production of pathogenic antibodies against self-molecules, culminating in inflammation and tissue damage. Target tissues can be from immune-vulnerable and immune-privileged sites. In view of the complex nature of autoimmune diseases, it is not surprising that they have long baffled immunologists, physicians and basic biomedical scientists who are struggling to combine known immunoinflammatory mechanisms into a unified general theory. The present seminar, organized by Euroscion, hosted a group of national and international scientists, affiliated to both academic and industrial research, to discuss state-of-the-art animal models for investigating pathomechanisms of autoimmune diseases, novel laboratory-based diagnostics and novel therapeutic prospects. The timely event on this important topic covered significant features of the basic pathomechanisms of autoimmune disease per se, the development of diagnostic and prognostic tests using functional biomarkers for monitoring patients and the development of targeted therapies. The absence of several prescheduled speakers allowed younger scientists, Stefan Kürten, Liliane Fossati-Jimack and Allan Holmes to shine. We are grateful for their participation. This meeting report describes key points and themes arising from this conference.
自身免疫性疾病是一组疾病，其中患者的免疫稳态变得如此失调，以至于它对宿主组织发起破坏性攻击。这些疾病的特征是自身反应性 T 和 B 细胞的激活，并且在某些情况下与针对自身分子的致病性抗体的产生有关，最终导致炎症和组织损伤。靶组织可以来自免疫脆弱和免疫特权部位。鉴于自身免疫性疾病的复杂性质，免疫学家、医生和基础生物医学科学家长期以来一直对它们感到困惑并不奇怪，他们正在努力将已知的免疫炎症机制整合到一个统一的一般理论中。本次研讨会由 Euroscion 组织，邀请了一群来自国内外的科学家，他们隶属于学术和工业研究，讨论了用于研究自身免疫性疾病发病机制的最新动物模型、基于实验室的新型诊断方法和新型治疗前景。这个重要主题的及时活动涵盖了自身免疫性疾病基本发病机制的重要特征、使用功能生物标志物监测患者的诊断和预后测试的开发以及靶向治疗的开发。几位预定发言人的缺席使年轻科学家 Stefan Kürten、Liliane Fossati-Jimack 和 Allan Holmes 有机会脱颖而出。我们感谢他们的参与。本会议报告描述了本次会议提出的要点和主题。
