Department of Forensic Medicine and Institute of Forensic Medicine, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Histopathology. 2011 Jan;58(2):191-7. doi: 10.1111/j.1365-2559.2011.03752.x.
CD151 is known to be implicated in cancer progression and metastasis. The aim was to evaluate the expression of CD151 in clear cell renal cell carcinoma (CCRCC) and to assess its prognostic significance.
The expression of CD151 was evaluated in 489 cases of CCRCC by immunohistochemistry. Immunoreactivity was classified into four categories (minimal, 0-10% positive cells; focal, 10-50% positive cells; diffuse moderate, >50% positive cells with moderate staining intensity; diffuse strong, >50% positive cells with strong staining). To determine the statistical significance of CD151 expression in CCRCC, all cases were divided into two groups based on their CD151 expression level: a CD151-low group (n=257; minimal and focal) and a CD151-high group (n=232; diffuse). Expression of CD151 was correlated positively with pT, pN, pM categories, pathological tumour-node-metastasis (pTNM) stage, nuclear grade, tumour size and patient's age. The CD151-high group had significantly shorter cancer-specific survival (P<0.001) and progression-free survival (P<0.001) times. Furthermore, multivariate analysis showed that CD151 expression was an independent predictor for tumour progression in patients with CCRCC (P=0.040).
High CD151 expression is associated with advanced stage and high nuclear grade in CCRCC. CD151 is a prognostic marker for tumour progression in CCRCC patients.
CD151 已知与癌症的进展和转移有关。本研究旨在评估 CD151 在透明细胞肾细胞癌（ccRCC）中的表达，并评估其预后意义。
通过免疫组织化学方法评估了 489 例 ccRCC 中 CD151 的表达。免疫反应性分为四个类别（最小，0-10%阳性细胞；局灶性，10-50%阳性细胞；弥漫性中度，>50%阳性细胞且染色强度中度；弥漫性强，>50%阳性细胞且染色强度强）。为了确定 CD151 在 ccRCC 中的表达的统计学意义，所有病例根据 CD151 表达水平分为两组：CD151 低组（n=257；最小和局灶性）和 CD151 高组（n=232；弥漫性）。CD151 的表达与 pT、pN、pM 分期、病理肿瘤-淋巴结-转移（pTNM）分期、核分级、肿瘤大小和患者年龄呈正相关。CD151 高组的癌症特异性生存（P<0.001）和无进展生存（P<0.001）时间明显缩短。此外，多变量分析显示，CD151 表达是 ccRCC 患者肿瘤进展的独立预测因子（P=0.040）。
CD151 高表达与 ccRCC 的晚期和高核分级有关。CD151 是 ccRCC 患者肿瘤进展的预后标志物。
