Division of Taiwan Cooperative Oncology Group, National Health Research Institutes, Zhu-Nan, Taiwan.
Cancer Nurs. 2011 Mar-Apr;34(2):117-23. doi: 10.1097/NCC.0b013e3181efe1c0.
Clinical trials provide information for developing new treatment strategies, enhancing cancer knowledge, and improving trial effectiveness. However, factors related to patients' participation in clinical trials have not been explored in Taiwan.
This study explored cancer patients' willingness to participate in clinical trials and motivational factors, barriers, needs, expectations, and other factors influencing their decision making.
In this cross-sectional study, information was collected using structured questionnaires with cancer patients from an academic medical center.
Among 184 cancer patients sampled, most (87.5%) were willing to participate in a clinical trial. Their attitude toward participating in clinical trials was positive (average motivational score = 59.09; highest scoring item was "chance of cure"). Participants had a slight barrier level for participating in clinical trials (average barrier score = 21.51; highest scoring item was "concern over adverse effects of drugs used in clinical trials"). They had strong needs for clinical trial participation (average need factors score = 59.24; highest scoring need item was "supply of clinical trial-related information by medical personnel, including study purpose, adverse effects, effectiveness, and notices"). Participants had expectations of clinical trial participation (average expectations score = 66.58; highest scoring item was "nonrecurrence of tumor"). Factors predicting participation in clinical trials included medical issues and subjective viewpoint.
These study results can help clinical researchers understand cancer patients' willingness to participate in clinical trials and other influencing factors.
Clinical research nurses can use this information in discussions with cancer patients and important stakeholders to help eligible patients better understand clinical trials to make informed decisions about participation.
临床试验为制定新的治疗策略、提高癌症知识水平和增强试验效果提供了信息。然而，在台湾，尚未探讨与患者参与临床试验相关的因素。
本研究旨在探讨癌症患者参与临床试验的意愿和动机因素、障碍因素、需求因素、期望因素以及影响其决策的其他因素。
本横断面研究采用结构问卷，从一家学术医疗中心采集癌症患者的信息。
在抽取的 184 例癌症患者中，大多数（87.5%）愿意参加临床试验。他们对参与临床试验的态度是积极的（平均动机评分=59.09；得分最高的项目是“治愈机会”）。参与者参与临床试验的障碍程度较低（平均障碍评分=21.51；得分最高的项目是“对临床试验中使用的药物的不良反应的担忧”）。他们对参与临床试验的需求强烈（平均需求因素评分=59.24；得分最高的需求项目是“医务人员提供临床试验相关信息，包括研究目的、不良反应、效果和通知”）。参与者对参与临床试验有期望（平均期望评分=66.58；得分最高的项目是“肿瘤不复发”）。预测参与临床试验的因素包括医疗问题和主观观点。
这些研究结果可以帮助临床研究人员了解癌症患者参与临床试验的意愿和其他影响因素。
临床研究护士可以将这些信息用于与癌症患者和重要利益相关者的讨论中，以帮助符合条件的患者更好地了解临床试验，从而做出知情参与的决策。
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