Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria 8006, Australia.
Nat Rev Cancer. 2011 Mar;11(3):199-210. doi: 10.1038/nrc3018. Epub 2011 Feb 17.
Cohesin is a conserved multisubunit protein complex with diverse cellular roles, making key contributions to the coordination of chromosome segregation, the DNA damage response and chromatin regulation by epigenetic mechanisms. Much has been learned in recent years about the roles of cohesin in a physiological context, whereas its potential and emerging role in tumour initiation and/or progression has received relatively little attention. In this Opinion article we examine how cohesin deregulation could contribute to cancer development on the basis of its physiological roles.
黏合蛋白是一种保守的多亚基蛋白复合物，具有多种细胞功能，为染色体分离、DNA 损伤反应以及通过表观遗传机制调控染色质的协调做出了重要贡献。近年来，人们对黏合蛋白在生理环境中的作用有了更多的了解，而其在肿瘤起始和/或进展中的潜在和新兴作用相对较少受到关注。在这篇观点文章中，我们根据黏合蛋白的生理作用来探讨其失调如何促进癌症的发展。
