Gerodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Kita-13 Nishi-7, Kita-ku, Sapporo 060-8586, Japan.
Support Care Cancer. 2012 Feb;20(2):367-73. doi: 10.1007/s00520-011-1116-x. Epub 2011 Feb 15.
Little is known about the effects of professional oral health care (POHC) on the outcome of hematopoietic stem cell transplantation (HSCT). We evaluated the effects of POHC given by dentists and dental hygienists on the development of oral mucositis and febrile neutropenia (FN) after allogeneic bone marrow transplantation (BMT).
We retrospectively studied 140 adult patients who had received allogeneic BMT, with or without POHC, in our hospital consecutively between February 2002 and December 2009. Oral mucositis was evaluated according to the World Health Organization scale.
The incidence of oral mucositis was 66.7% (52/78) in the patients who had received POHC, compared to 93.5% (58/62) in the non-POHC group (P < 0.001). The incidence of FN and the maximal level of CRP were also significantly lower in the POHC group. Multivariate analysis revealed that the POHC was significantly associated with the incidence of oral mucositis (odds ratio, 7.58; 95%CI, 2.45-23.34; P < 0.001).
We concluded that POHC reduced the incidences of oral mucositis and FN by upgrading the overall oral hygiene during HSCT.
对于专业口腔保健（POHC）对造血干细胞移植（HSCT）结果的影响知之甚少。我们评估了牙医和牙科保健员提供的 POHC 对异基因骨髓移植（BMT）后口腔粘膜炎和发热性中性粒细胞减少（FN）发展的影响。
我们回顾性研究了 2002 年 2 月至 2009 年 12 月在我院连续接受异基因 BMT 的 140 例成年患者，这些患者接受了或未接受 POHC。口腔粘膜炎根据世界卫生组织（WHO）量表进行评估。
接受 POHC 的患者口腔粘膜炎发生率为 66.7%（52/78），而未接受 POHC 的患者为 93.5%（58/62）（P<0.001）。POHC 组 FN 的发生率和 CRP 的最高水平也明显较低。多变量分析显示，POHC 与口腔粘膜炎的发生显著相关（比值比，7.58；95%CI，2.45-23.34；P<0.001）。
我们得出结论，POHC 通过在 HSCT 期间改善整体口腔卫生，降低了口腔粘膜炎和 FN 的发生率。
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