School of Psychology and Institute of Neuroscience, University of Nottingham, Nottingham, UK.
Curr Opin Neurobiol. 2011 Jun;21(3):492-501. doi: 10.1016/j.conb.2011.01.003. Epub 2011 Feb 15.
How is hippocampal learning, including place learning, translated into behavior? The hippocampus integrates, along its septotemporal axis, substrates of rapid place learning, including entorhinal-hippocampal connectivity, with functional connectivity to subcortical sites and prefrontal cortex, which play central roles in behavioral-control functions, including sensorimotor, emotional, motivational, attentional, and executive functions. I present recent evidence that such integration, for which the intermediate hippocampus is a key neuroanatomical substrate, enables translation of rapid place learning into adaptive behavior. What are the clinical implications of the hippocampal learning-behavior translation? Focusing on hippocampal overactivity, which has emerged as a central feature of schizophrenia pathophysiology, I highlight how, due to functional connectivity enabling the learning-behavior translation, hippocampal dysfunction may cause not only memory deficits, but also neural-network disruptions underlying psychosis and attentional and executive deficits.
海马体学习，包括位置学习，如何转化为行为？海马体沿着其隔颞轴整合了快速位置学习的基质，包括内嗅皮层-海马体连接，以及与皮质下部位和前额叶的功能连接，这些部位在行为控制功能中起着核心作用，包括感觉运动、情感、动机、注意力和执行功能。我提出了最近的证据表明，这种整合是快速位置学习转化为适应性行为的关键神经解剖学基础。海马体学习-行为转化的临床意义是什么？本文关注海马体过度活跃，这已成为精神分裂症病理生理学的一个核心特征，我强调了由于功能连接使学习-行为转化成为可能，海马体功能障碍不仅会导致记忆缺陷，还会导致神经网络紊乱，从而导致精神分裂症和注意力及执行功能缺陷。
