Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea.
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, United States.
Elife. 2024 Jul 16;13:RP97114. doi: 10.7554/eLife.97114.
Goal-directed navigation requires the hippocampus to process spatial information in a value-dependent manner, but its underlying mechanism needs to be better understood. Here, we investigated whether the dorsal (dHP) and intermediate (iHP) regions of the hippocampus differentially function in processing place and its associated value information. Rats were trained in a place-preference task involving reward zones with different values in a visually rich virtual reality environment where two-dimensional navigation was possible. Rats learned to use distal visual scenes effectively to navigate to the reward zone associated with a higher reward. Inactivation of both dHP and iHP with muscimol altered the efficiency and precision of wayfinding behavior, but iHP inactivation induced more severe damage, including impaired place preference. Our findings suggest that the iHP is more critical for value-dependent navigation toward higher-value goal locations.
目标导向导航需要海马体以依赖于价值的方式处理空间信息，但需要更好地理解其潜在机制。在这里，我们研究了海马体的背侧（dHP）和中间（iHP）区域是否在处理位置及其相关价值信息方面存在差异。在一个视觉丰富的虚拟现实环境中，大鼠在涉及不同价值奖励区的位置偏好任务中接受训练，在该环境中可以进行二维导航。大鼠学会有效地使用远距离视觉场景来导航到与更高奖励相关的奖励区。用 muscimol 对 dHP 和 iHP 进行失活会改变寻路行为的效率和准确性，但 iHP 失活会导致更严重的损伤，包括受损的位置偏好。我们的研究结果表明，iHP 对于朝着更高价值目标位置的价值依赖导航更为关键。
