Department of Surgical Sciences, Section of Surgery, Uppsala University Hospital, SE 751 85 Uppsala, Sweden.
Eur J Vasc Endovasc Surg. 2011 May;41(5):663-7. doi: 10.1016/j.ejvs.2011.01.009. Epub 2011 Feb 16.
Is it possible by pharmacological methods to attenuate the expansion rate of abdominal aortic aneurysms?
An Internet-based systematic literature search was performed to identify published reports on pharmacological methods to influence aneurysmal expansion rate.
Of an original 450 articles, 21 remained to review: they included 15 cohort studies with 12,321 patients and seven randomised clinical trials (RCTs) with 1069 patients. Most studies are performed without a pre-study sample size calculation. There is no consistent pattern of pharmacological influence on expansion rate, but statins, non-steroidal anti-inflammatory drugs (NSAIDs) and macrolides should be further evaluated.
Properly designed RCTs are needed before conclusions can be drawn on the possibility to pharmacologically attenuate aneurysmal expansion and prevent rupture.
是否可以通过药理学方法减缓腹主动脉瘤的扩张速度？
进行了基于互联网的系统文献检索，以确定关于影响动脉瘤扩张速度的药理学方法的已发表报告。
最初的 450 篇文章中，有 21 篇进行了回顾：它们包括 15 项队列研究，涉及 12321 名患者和 7 项随机临床试验（RCT），涉及 1069 名患者。大多数研究都没有进行预研究样本量计算。目前尚无关于药理学对扩张率影响的一致模式，但他汀类药物、非甾体抗炎药（NSAIDs）和大环内酯类药物值得进一步评估。
在得出关于用药物方法减缓动脉瘤扩张和预防破裂的可能性的结论之前，需要进行精心设计的 RCT。
