Alexandrov V, Aiello C, Rossi L
Laboratory of Preclinical Trials, N.N. Petrov Research Institute of Oncology, Leningrad, USSR.
In Vivo. 1990 Sep-Oct;4(5):327-35.
A description of the experimental approaches devised to control the growth of tumors induced by transplacental exposure to carcinogens is given. Due to the massive cell proliferation and differentiation taking place during embryogenesis, fetal tissues are believed to be privileged targets of neoplastic changes. As a consequence, trace amounts of environmental carcinogens capable of accumulating into the conceptuses may determine the appearance of tumors in the offspring, a possibility documented in several animal species including humans. Endogenous and exogenous factors counteracting this process have potential application as regulators of developmental carcinogenesis. Their identification is regarded as a means to chemoprevent pediatric tumors and can be instrumental in the analysis of the aetiopathogenesis of neoplastic phenotypes.
本文描述了为控制经胎盘接触致癌物诱导的肿瘤生长而设计的实验方法。由于胚胎发育过程中发生大量细胞增殖和分化，胎儿组织被认为是肿瘤性变化的优先靶点。因此，能够在胚胎中蓄积的痕量环境致癌物可能会导致后代出现肿瘤，这一可能性已在包括人类在内的多种动物物种中得到证实。对抗这一过程的内源性和外源性因素具有作为发育性致癌作用调节剂的潜在应用价值。它们的识别被视为预防儿童肿瘤的一种手段，并且有助于分析肿瘤表型的病因发病机制。
