Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Obesity (Silver Spring). 2011 Jul;19(7):1415-9. doi: 10.1038/oby.2011.21. Epub 2011 Feb 17.
Oxidative stress and inflammation have not been well-characterized in extreme pediatric obesity. We compared levels of circulating oxidized low-density lipoprotein (oxLDL), C-reactive protein (CRP), and interleukin-6 (IL-6) in extremely obese (EO) children to normal weight (NW) and overweight/obese (OW/OB) children. OxLDL, CRP, IL-6, BMI, blood pressure, and fasting glucose, insulin, and lipids were obtained in 225 children and adolescents (age 13.5 ± 2.5 years; boys 55%). Participants were classified into three groups based on gender- and age-specific BMI percentile: NW (<85th, n = 127), OW/OB (85th- <1.2 times the 95th percentile, n = 64) and EO (≥1.2 times the 95th percentile or BMI ≥35 kg/m(2), n = 34). Measures were compared across groups using analysis of covariance, adjusted for gender, age, and race. Blood pressure, insulin, and lipids worsened across BMI groups (all P < 0.0001). OxLDL (NW: 40.8 ± 9.0 U/l, OW/OB: 45.7 ± 12.1 U/l, EO: 63.5 ± 13.8 U/l) and CRP (NW: 0.5 ± 1.0 mg/l, OW/OB: 1.4 ± 2.9 mg/l, EO: 5.6 ± 4.9 mg/l) increased significantly across BMI groups (all groups differed with P < 0.01). IL-6 was significantly higher in EO (2.0 ± 0.9 pg/ml) compared to OW/OB (1.3 ± 1.2 pg/ml, P < 0.001) and NW (1.1 ± 1.0 pg/ml, P < 0.0001) but was not different between NW and OW/OB. Extreme pediatric obesity, compared to milder forms of adiposity and NW, is associated with higher levels of oxidative stress and inflammation, suggesting that markers of early cardiovascular disease and type 2 diabetes mellitus are already present in this young population.
在极端儿科肥胖症中，氧化应激和炎症尚未得到很好的描述。我们比较了极度肥胖（EO）儿童与正常体重（NW）和超重/肥胖（OW/OB）儿童循环氧化型低密度脂蛋白（oxLDL）、C 反应蛋白（CRP）和白细胞介素-6（IL-6）的水平。在 225 名 13.5 ± 2.5 岁的儿童和青少年（男 55%）中获得了 oxLDL、CRP、IL-6、BMI、血压、空腹血糖、胰岛素和血脂。根据性别和年龄特异性 BMI 百分位数，将参与者分为三组：NW（<85%，n = 127）、OW/OB（85%-<1.2 倍 95%，n = 64）和 EO（≥1.2 倍 95%或 BMI ≥35 kg/m²，n = 34）。使用协方差分析比较了各组之间的指标，调整了性别、年龄和种族因素。血压、胰岛素和血脂随 BMI 组的增加而恶化（均 P < 0.0001）。OxLDL（NW：40.8 ± 9.0 U/l，OW/OB：45.7 ± 12.1 U/l，EO：63.5 ± 13.8 U/l）和 CRP（NW：0.5 ± 1.0 mg/l，OW/OB：1.4 ± 2.9 mg/l，EO：5.6 ± 4.9 mg/l）随 BMI 组的增加而显著增加（各组之间差异均 P < 0.01）。与 OW/OB（1.3 ± 1.2 pg/ml，P < 0.001）和 NW（1.1 ± 1.0 pg/ml，P < 0.0001）相比，EO 组的 IL-6 明显更高（2.0 ± 0.9 pg/ml），但 NW 和 OW/OB 之间的差异无统计学意义。与轻度肥胖和 NW 相比，极端儿科肥胖症与更高水平的氧化应激和炎症相关，这表明在这个年轻人群中，心血管疾病和 2 型糖尿病的早期标志物已经存在。
