神经科学在脑屏障生物学转化研究中的应用。
Engaging neuroscience to advance translational research in brain barrier biology.
机构信息
Oregon Health & Science University, 3181 SW Sam Jackson Park Road L603, Portland, Oregon 97239-2941, USA.
出版信息
Nat Rev Neurosci. 2011 Mar;12(3):169-82. doi: 10.1038/nrn2995.
Abstract
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
摘要
许多具有潜在治疗和诊断作用的化合物向大脑特定区域的递送受到脑屏障的限制，其中最为人熟知的是血脑屏障（BBB）和血脑脊液（CSF）屏障。最近的研究表明，这些屏障具有许多额外的作用，包括参与神经发育、控制脑血流，以及在血脑屏障完整性受损时，参与许多常见中枢神经系统疾病（如阿尔茨海默病、帕金森病和中风）的病理过程。
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