Petkova Mima Ivanova, Pujol-Carrion Nuria, de la Torre-Ruiz Maria Angeles
Departament de Ciíncies Mídiques Bàsiques-IRBLleida; Facultad de Medicina; Universidad de Lleida; Lleida, Spain.
Commun Integr Biol. 2010 Nov;3(6):555-7. doi: 10.4161/cib.3.6.12974. Epub 2010 Nov 1.
The CWI pathway cross-talks with TOR and RAS in both the oxidative and glucose starvation responses. Mtl1 is the cell-wall protein in charge of sensing and regulating this response. Rom2 and Rho1, which are the upper elements in the pathway, mediate this signal. Several outputs are involved and required for this response, one of which, ribosomal gene expression, seems to be regulated by Sfp1, amongst other possible transcription factors. Moreover, cross-talk also occurs in a reverse flow from TOR and RAS to the CWI pathway. Thus Tor1 and Ras2 inhibition also activates Slt2 in the absence of the Mtl1 protein and assures the proper adaptive response to oxidation and glucose deprivation.
在氧化应激和葡萄糖饥饿反应中，CWI途径与TOR和RAS相互作用。Mtl1是负责感知和调节这种反应的细胞壁蛋白。Rom2和Rho1是该途径中的上游元件，介导这一信号。这种反应涉及多个输出且是必需的，其中之一是核糖体基因表达，除其他可能的转录因子外，它似乎受Sfp1调节。此外，TOR和RAS到CWI途径也存在反向的相互作用。因此，在没有Mtl1蛋白的情况下，Tor1和Ras2的抑制也会激活Slt2，并确保对氧化和葡萄糖剥夺做出适当的适应性反应。
