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肿瘤细胞组织侵袭和迁移模型的数值解。

Numerical solutions for a model of tissue invasion and migration of tumour cells.

机构信息

Department of Mathematics and Computer Science, University of Warmia and Mazury, Zolnierska 14, 10-561 Olsztyn, Poland.

出版信息

Comput Math Methods Med. 2011;2011:452320. doi: 10.1155/2011/452320. Epub 2010 Dec 30.

Abstract

The goal of this paper is to construct a new algorithm for the numerical simulations of the evolution of tumour invasion and metastasis. By means of mathematical model equations and their numerical solutions we investigate how cancer cells can produce and secrete matrix degradative enzymes, degrade extracellular matrix, and invade due to diffusion and haptotactic migration. For the numerical simulations of the interactions between the tumour cells and the surrounding tissue, we apply numerical approximations, which are spectrally accurate and based on small amounts of grid-points. Our numerical experiments illustrate the metastatic ability of tumour cells.

摘要

本文旨在构建一种新的算法,用于肿瘤侵袭和转移演变的数值模拟。通过数学模型方程及其数值解,我们研究了癌细胞如何产生和分泌基质降解酶、降解细胞外基质,并通过扩散和趋化性迁移进行侵袭。对于肿瘤细胞与周围组织相互作用的数值模拟,我们应用了谱精确且基于少量网格点的数值逼近方法。我们的数值实验说明了肿瘤细胞的转移能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f82/3017898/8a2fd1538039/CMMM2011-452320.001.jpg

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