表面束缚蛋白开关。

Surface-tethered protein switches.

机构信息

Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

出版信息

Chem Commun (Camb). 2011 Mar 28;47(12):3398-400. doi: 10.1039/c1cc10146c. Epub 2011 Feb 18.

Abstract

Protein switches are engineered fusion proteins with an input domain that recognizes and responds to an input signal and an output domain whose function is regulated by the state of the input domain. Here we demonstrate a fully functional surface tethered protein switch that offers a potential route to a universal biosensing platform.

摘要

蛋白质开关是一种工程融合蛋白，具有一个输入结构域，该结构域识别并响应输入信号，以及一个输出结构域，其功能受输入结构域状态的调节。在这里，我们展示了一种完全功能的表面连接的蛋白质开关，它为通用生物传感平台提供了一种潜在途径。